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Background <p>Non-invasive oxygenation techniques lower the risk of ventilator-associated complications in cases of acute respiratory failure (ARF). Employing specific scoring systems derived from lung ultrasound (U/S) can predict failure of non-invasive respiratory support (NIRS), thereby reducing the use of mechanical ventilation (MV) and its associated complications.</p> Objectives <p>To assess the ability of different chest U/S scores to predict failure of NIRS methods in comparison with other scores, e.g., HACOR score, Acute Physiology and Chronic Health Evaluation (APACHE II), Respiratory rate–Oxygenation index (ROX), and the partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2/FiO2) ratio.</p> Methods <p>Eighty-two patients presenting with ARF (type I and II) were managed with high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV). Routine laboratory tests were performed. Lung ultrasound score (LUS), diaphragmatic thickening fraction (DTF), ROX, HACOR, APACHE II, and PaO2/FiO2 ratio were calculated on admission and after 48&#xa0;h.</p> Results <p>Among the 82 patients enrolled in this study, 20 (16 succeeded and 4 failed) were treated with NIV, and 62 (46 succeeded and 16 failed) were treated with HFNC. Comparisons between LUS, DTF, ROX, HACOR, APACHE II, and P/F ratio were performed. ROX index, HACOR score, APACHE II score, and DTF were able to predict failure of NIRS, and also predicted failure after 48&#xa0;h of admission, in addition to the P/F ratio.</p> Conclusion <p>ROX index, P/F ratio, DTF, and APACHE II were able to predict failure of NIRS, with APACHE II being the most accurate on admission day. LUS was not significant.</p>

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A prospective observational study comparing lung ultrasound and clinical scores ability in prediction of non invasive respiratory support outcome in acute respiratory failure

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月25日

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  • Abeer Salah El-deen Mohammed,
  • Randa Salah El-deen Mohammed,
  • Ahmed Sayed Abd El Basset,
  • Omnia Adel Saad Zaghloul Mohammed,
  • Maha Fathy Mohamed,
  • Noha Mahmoud Fahmy

摘要

Background

Non-invasive oxygenation techniques lower the risk of ventilator-associated complications in cases of acute respiratory failure (ARF). Employing specific scoring systems derived from lung ultrasound (U/S) can predict failure of non-invasive respiratory support (NIRS), thereby reducing the use of mechanical ventilation (MV) and its associated complications.

Objectives

To assess the ability of different chest U/S scores to predict failure of NIRS methods in comparison with other scores, e.g., HACOR score, Acute Physiology and Chronic Health Evaluation (APACHE II), Respiratory rate–Oxygenation index (ROX), and the partial pressure of arterial oxygen to fraction of inspired oxygen (PaO2/FiO2) ratio.

Methods

Eighty-two patients presenting with ARF (type I and II) were managed with high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV). Routine laboratory tests were performed. Lung ultrasound score (LUS), diaphragmatic thickening fraction (DTF), ROX, HACOR, APACHE II, and PaO2/FiO2 ratio were calculated on admission and after 48 h.

Results

Among the 82 patients enrolled in this study, 20 (16 succeeded and 4 failed) were treated with NIV, and 62 (46 succeeded and 16 failed) were treated with HFNC. Comparisons between LUS, DTF, ROX, HACOR, APACHE II, and P/F ratio were performed. ROX index, HACOR score, APACHE II score, and DTF were able to predict failure of NIRS, and also predicted failure after 48 h of admission, in addition to the P/F ratio.

Conclusion

ROX index, P/F ratio, DTF, and APACHE II were able to predict failure of NIRS, with APACHE II being the most accurate on admission day. LUS was not significant.