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Background <p>Usual interstitial pneumonia (UIP) pattern indicates interstitial lung disease (ILD) with a poor prognosis. Despite its varied course, COVID-19 and cardiovascular comorbidities may exacerbate disease development.</p> Case presentation <p>We present two female cases with UIP pattern-ILD with divergent clinical trajectories. The first, aged 51, had no history of COVID-19 or cardiovascular disease and declined over three years before dying of respiratory failure. The second, aged 63, with severe COVID-19 infection, coronary artery disease, and heart failure, rapidly worsened and died three months after diagnosis. These cases illustrate how systemic variables—aging, cardiovascular failure, and post-COVID-19 inflammation—might influence UIP-pattern ILD. These disparate instances highlight the interaction of inflammation, vascular impairment, and immunological response in ILD.</p> Conclusion <p>In UIP-pattern ILD female patients, age, COVID-19, and cardiovascular comorbidities appear to significantly impact disease dynamics, negatively influencing disease course and survival outcomes.</p>

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The influence of age, COVID-19, and cardiovascular disease on female usual interstitial pneumonia pattern-interstitial lung disease: case series

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月25日

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  • Martha F. A. Tatodi,
  • Susanthy Djajalaksana,
  • Suryanti D. Pratiwi,
  • Iin N. Chozin,
  • Wella Karolina,
  • Dini R. Erawati

摘要

Background

Usual interstitial pneumonia (UIP) pattern indicates interstitial lung disease (ILD) with a poor prognosis. Despite its varied course, COVID-19 and cardiovascular comorbidities may exacerbate disease development.

Case presentation

We present two female cases with UIP pattern-ILD with divergent clinical trajectories. The first, aged 51, had no history of COVID-19 or cardiovascular disease and declined over three years before dying of respiratory failure. The second, aged 63, with severe COVID-19 infection, coronary artery disease, and heart failure, rapidly worsened and died three months after diagnosis. These cases illustrate how systemic variables—aging, cardiovascular failure, and post-COVID-19 inflammation—might influence UIP-pattern ILD. These disparate instances highlight the interaction of inflammation, vascular impairment, and immunological response in ILD.

Conclusion

In UIP-pattern ILD female patients, age, COVID-19, and cardiovascular comorbidities appear to significantly impact disease dynamics, negatively influencing disease course and survival outcomes.