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Background <p>Ventilator-associated pneumonia (VAP) is a frequent nosocomial infection in patients undergoing cardiac surgery, contributing to prolonged hospitalization and increased healthcare burden. This study aimed to evaluate the impact of VAP on clinical outcomes and identify independent risk factors in cardiac surgical intensive care unit (CSICU) patients, leveraging real-world data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.</p> Methods <p>A retrospective cohort analysis was conducted on 5,975 patients receiving invasive mechanical ventilation in the CSICU, with VAP cases identified using ICD codes (‘99731’ and ‘J95851’), including 161 VAP cases. Propensity score matching (PSM) was applied to balance covariates. Statistical analyses included Mann–Whitney U and chi-square tests for group comparisons, followed by univariable and multivariable logistic regression to identify VAP risk factors, with model diagnostics ensuring robustness.</p> Results <p>The VAP incidence was 19.68 per 1,000 ventilator-days. Before PSM, VAP patients had higher in-hospital mortality (20% vs. 4%, <i>P</i> &lt; 0.05) and longer ICU/hospital stays. After PSM, mortality did not differ significantly (20% vs. 23%, <i>P</i> = 0.50), but ICU stays (21.47 vs. 13.19 days) and hospital stays (28.38 vs. 18.64 days) remained significantly prolonged (<i>P</i> &lt; 0.05). Multivariable analysis identified aortic aneurysm dissection (OR = 1.61), higher Charlson Comorbidity Index (OR = 1.15), higher positive end-expiratory pressure (OR = 1.28), and higher minute volume (OR = 1.72) as independent risk factors, while higher fraction of inspired oxygen was protective (OR = 0.89).</p> Conclusions <p>VAP significantly extends ICU and hospital stays without increasing attributable mortality in cardiac surgery patients. Key modifiable risk factors include ventilator settings and patient-specific factors. Targeted interventions on these factors may reduce VAP incidence and improve resource utilization.</p>

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Relationship between ventilator-associated pneumonia and prognosis among patients in cardiac surgical intensive care units: a retrospective analysis based on the MIMIC database

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月22日

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  • Bo Song,
  • Guanjun Jiang,
  • Yujia Liu,
  • Dongsheng Cheng

摘要

Background

Ventilator-associated pneumonia (VAP) is a frequent nosocomial infection in patients undergoing cardiac surgery, contributing to prolonged hospitalization and increased healthcare burden. This study aimed to evaluate the impact of VAP on clinical outcomes and identify independent risk factors in cardiac surgical intensive care unit (CSICU) patients, leveraging real-world data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.

Methods

A retrospective cohort analysis was conducted on 5,975 patients receiving invasive mechanical ventilation in the CSICU, with VAP cases identified using ICD codes (‘99731’ and ‘J95851’), including 161 VAP cases. Propensity score matching (PSM) was applied to balance covariates. Statistical analyses included Mann–Whitney U and chi-square tests for group comparisons, followed by univariable and multivariable logistic regression to identify VAP risk factors, with model diagnostics ensuring robustness.

Results

The VAP incidence was 19.68 per 1,000 ventilator-days. Before PSM, VAP patients had higher in-hospital mortality (20% vs. 4%, P < 0.05) and longer ICU/hospital stays. After PSM, mortality did not differ significantly (20% vs. 23%, P = 0.50), but ICU stays (21.47 vs. 13.19 days) and hospital stays (28.38 vs. 18.64 days) remained significantly prolonged (P < 0.05). Multivariable analysis identified aortic aneurysm dissection (OR = 1.61), higher Charlson Comorbidity Index (OR = 1.15), higher positive end-expiratory pressure (OR = 1.28), and higher minute volume (OR = 1.72) as independent risk factors, while higher fraction of inspired oxygen was protective (OR = 0.89).

Conclusions

VAP significantly extends ICU and hospital stays without increasing attributable mortality in cardiac surgery patients. Key modifiable risk factors include ventilator settings and patient-specific factors. Targeted interventions on these factors may reduce VAP incidence and improve resource utilization.