Background <p>Juvenile psoriatic arthritis (JPsA) is one of progressive idiopathic arthritis that affects children with psoriasis. The transition from cutaneous to arthritis development may be linked to genetic and clinical-demographic risk factors. However, the true events responsible for this transition are currently unclear. Thus, this cross-sectional study aimed to evaluate clinical risk factors among children with JPsA that may be involved in arthritis development. 40 children with psoriasis without arthritis (group I) were enrolled in this study, besides 40 children with JPsA (group II). All patients were subjected to full history taking, clinical examination, assessment of psoriasis severity by PASI score, laboratory assessment, and body mass index (BMI) calculation.</p> Results <p>No significant difference was detected between the two groups regarding age, sex, or family history of psoriasis. Also, 47.5% and 32.5% of group II were overweight and obese, respectively, compared to 2.5% and 15% in group I. The percentage of passive smoking was non-significantly higher among group II (37.5%) compared to group I (25%). Group II of the studied patients showed significantly higher levels of ESR and CRP (<i>P</i> &lt; 0.001). Sixty-five percent of group II had nail psoriasis compared to 22.5% of group I (<i>P</i> &lt; 0.001). By binary logistic regression, overweight, obesity, and nail psoriasis were predictors for developing JPsA (<i>P</i> &lt; 0.05 and OR more than 1 with 95% CI).</p> Conclusion <p>Different clinical risk factors may be involved in the development of JPsA in children with psoriasis, including higher BMI and nail psoriasis.</p>