Scholarlink

Background <p>Kaposi sarcoma (KS) is an angioproliferative malignancy driven by human herpesvirus 8 (HHV-8) that most often manifests as cutaneous lesions. Nodal involvement in HIV-negative, immunocompetent individuals, especially as an initial presentation, is exceedingly rare. Head and neck KS accounts for less than 5% of non-AIDS-associated cases, with cervical lymphadenopathy representing only 4.4% of lesion distributions in this population.</p> Case presentation <p>A 71-year-old HIV-negative Italian man presented with a painless, progressively enlarging submandibular lymphadenopathy. Surgical excision followed by histopathology and immunohistochemistry confirmed nodal KS. Subsequent full-body skin examination identified a previously unrecognized violaceous lesion on the hallux, which was histopathologically confirmed as KS.</p> Conclusions <p>This case highlights the diagnostic challenges posed by atypical KS presentations and emphasizes the need to include KS in the differential diagnosis of unexplained cervical lymphadenopathy, even in immunocompetent patients without clinically evident cutaneous lesions. Comprehensive dermatologic screening and long-term multidisciplinary surveillance are advised to detect and manage potential disease progression.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Submandibular nodal involvement as the initial presentation of HIV-negative Kaposi sarcoma: a case report

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月20日

查看全文
  • Matteo Caria,
  • Beatrice Enrica Fabiano,
  • Paola Campisi,
  • Carmine Prizio,
  • Vittorio Ferrero,
  • Andrea Lorenzi

摘要

Background

Kaposi sarcoma (KS) is an angioproliferative malignancy driven by human herpesvirus 8 (HHV-8) that most often manifests as cutaneous lesions. Nodal involvement in HIV-negative, immunocompetent individuals, especially as an initial presentation, is exceedingly rare. Head and neck KS accounts for less than 5% of non-AIDS-associated cases, with cervical lymphadenopathy representing only 4.4% of lesion distributions in this population.

Case presentation

A 71-year-old HIV-negative Italian man presented with a painless, progressively enlarging submandibular lymphadenopathy. Surgical excision followed by histopathology and immunohistochemistry confirmed nodal KS. Subsequent full-body skin examination identified a previously unrecognized violaceous lesion on the hallux, which was histopathologically confirmed as KS.

Conclusions

This case highlights the diagnostic challenges posed by atypical KS presentations and emphasizes the need to include KS in the differential diagnosis of unexplained cervical lymphadenopathy, even in immunocompetent patients without clinically evident cutaneous lesions. Comprehensive dermatologic screening and long-term multidisciplinary surveillance are advised to detect and manage potential disease progression.