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Background <p>COVID-19 patients present with increased oxidative stress and inflammatory storm that affects the olfactory bulb and epithelium, and this may be related to a reduction in selenium and glutathione activity in post-COVID-19. The correlations between anosmia in COVID-19 and both host Se and GXR-6 status provide important context.</p> Objectives <p>This study tries to describe the relation between serum GPX6 and the expression of the GPX6 gene in post-COVID-19 presented with anosmia in Mosul governorate—Iraq.</p> Patients and methods <p>This case-control study is concerned with 27 patients presented with disturbance of the sense of smell following COVID-19 infection (Group I) who underwent serum GPX6 level evaluation. Expression changes in GPX6 gene evaluation were compared with the corresponding results of 50 age-matched persons (volunteers) with normal olfaction (Group II). These patients were collected from the Outpatient Department of ENT at Al-Jamhory Teaching Hospital, Mosul, Iraq, and the private clinics of the authors for the period from Feb. 2021 to Jan. 2023.</p> Results <p>The study included 27 patients who presented with disturbance of the sense of smell persisting 3 months following COVID-19 infection (Group I), with a mean age of 30.5 ± 10 years and a range of 17–48 years. There were 10 male patients (37%) and 17 females (63%). The peak age incidence was in the 3rd decade of life. Serum GPX6 was significantly lower in patients in comparison to the control group. In addition, the fold change GPX6 mRNA expression showed significant reduction in the patient group in comparison to the control group. Serum GPX6 level in both the control and patient groups showed no significant correlation with GPX6 gene expression.</p> Conclusion <p>In post-COVID-19 with anosmia patients, serum GPX6 and the expression of the GPX6 gene showed significant reduction in comparison to the control group.</p>

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Role of glutathione-peroxidase 6 activity in post-COVID-19 olfactory dysfunction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月19日

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  • Ali A. Mohammed,
  • Muhammad A. A. Alkataan,
  • Haitham A. Alnori,
  • Bara’a M. Aziz,
  • Raghdan M. Dawood,
  • Mohammed S. Sheet

摘要

Background

COVID-19 patients present with increased oxidative stress and inflammatory storm that affects the olfactory bulb and epithelium, and this may be related to a reduction in selenium and glutathione activity in post-COVID-19. The correlations between anosmia in COVID-19 and both host Se and GXR-6 status provide important context.

Objectives

This study tries to describe the relation between serum GPX6 and the expression of the GPX6 gene in post-COVID-19 presented with anosmia in Mosul governorate—Iraq.

Patients and methods

This case-control study is concerned with 27 patients presented with disturbance of the sense of smell following COVID-19 infection (Group I) who underwent serum GPX6 level evaluation. Expression changes in GPX6 gene evaluation were compared with the corresponding results of 50 age-matched persons (volunteers) with normal olfaction (Group II). These patients were collected from the Outpatient Department of ENT at Al-Jamhory Teaching Hospital, Mosul, Iraq, and the private clinics of the authors for the period from Feb. 2021 to Jan. 2023.

Results

The study included 27 patients who presented with disturbance of the sense of smell persisting 3 months following COVID-19 infection (Group I), with a mean age of 30.5 ± 10 years and a range of 17–48 years. There were 10 male patients (37%) and 17 females (63%). The peak age incidence was in the 3rd decade of life. Serum GPX6 was significantly lower in patients in comparison to the control group. In addition, the fold change GPX6 mRNA expression showed significant reduction in the patient group in comparison to the control group. Serum GPX6 level in both the control and patient groups showed no significant correlation with GPX6 gene expression.

Conclusion

In post-COVID-19 with anosmia patients, serum GPX6 and the expression of the GPX6 gene showed significant reduction in comparison to the control group.