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Background <p>Treating patients with proton pump inhibitors (PPIs) has been proposed&#xa0;to&#xa0;be effective in reducing pharyngeal pain as well as dysphagia reported by patients after thyroid surgery.</p> Objectives <p>This work aims&#xa0;at evaluating the effect&#xa0;of administration of PPIs on swallowing impairment symptoms after traditional thyroidectomy.</p> Methods <p>&#xa0;This prospective randomized controlled study included 30 patients, with an age range between 18 and 60&#xa0;years, both genders, undergoing thyroid surgery for various indications, and able to complete&#xa0;swallowing impairment score (SIS)&#xa0;questionnaire. Study population was divided into treatment and control groups. Treatment group&#xa0;patients received oral PPIs 1&#xa0;week preoperative and continued to 2&#xa0;weeks postoperative.</p> Results <p>Always feeling a throat obstacle during swallowing and occasionally having some difficulties in swallowing fluids were significantly greater within the treatment group as opposed to the control group (<i>P</i> = 0.016). Total of SIS the 1st day postoperative was insignificantly different between both groups. Occasionally, having some difficulties in swallowing fluids was significantly greater within the treatment group as opposed to the control group (<i>P</i> = 0.007). Total of SIS the 1st day postoperative exhibited a significant reduction within the treatment group as opposed to the control group (<i>P</i> &lt; 0.001). Total of SIS after 1st week postoperative exhibited highly significant variation among both groups.</p> Conclusions <p>Peri-operative use of PPIs could alleviate the swallowing disorders after thyroid surgery. Cases using PPIs exhibited reduced pain and swallowing impairment during the first week after thyroid surgery, when compared&#xa0;to the control group.</p>

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Evaluation of the effect of proton pump inhibitors on swallowing impairment symptoms after thyroidectomy

  • 期刊论文

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  • 发表日期：

    2025年8月6日

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  • Heba Elsayed Elghazouly,
  • Mahmoud Abdelghani Hagras,
  • Mahmoud Mandour,
  • Mostafa Ammar

摘要

Background

Treating patients with proton pump inhibitors (PPIs) has been proposed to be effective in reducing pharyngeal pain as well as dysphagia reported by patients after thyroid surgery.

Objectives

This work aims at evaluating the effect of administration of PPIs on swallowing impairment symptoms after traditional thyroidectomy.

Methods

 This prospective randomized controlled study included 30 patients, with an age range between 18 and 60 years, both genders, undergoing thyroid surgery for various indications, and able to complete swallowing impairment score (SIS) questionnaire. Study population was divided into treatment and control groups. Treatment group patients received oral PPIs 1 week preoperative and continued to 2 weeks postoperative.

Results

Always feeling a throat obstacle during swallowing and occasionally having some difficulties in swallowing fluids were significantly greater within the treatment group as opposed to the control group (P = 0.016). Total of SIS the 1st day postoperative was insignificantly different between both groups. Occasionally, having some difficulties in swallowing fluids was significantly greater within the treatment group as opposed to the control group (P = 0.007). Total of SIS the 1st day postoperative exhibited a significant reduction within the treatment group as opposed to the control group (P < 0.001). Total of SIS after 1st week postoperative exhibited highly significant variation among both groups.

Conclusions

Peri-operative use of PPIs could alleviate the swallowing disorders after thyroid surgery. Cases using PPIs exhibited reduced pain and swallowing impairment during the first week after thyroid surgery, when compared to the control group.