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Background <p>Hypertension is highly prevalent in chronic kidney disease (CKD) and contributes to cardiovascular complications and progressive renal dysfunction. Evaluating real-world antihypertensive prescribing patterns may help optimize blood pressure management in this high-risk population.</p> Methods <p>A six-month prospective observational study was conducted among 100 adults with CKD and hypertension attending a tertiary-care teaching hospital. Demographic characteristics, CKD stage, associated clinical conditions, antihypertensive prescriptions, blood pressure, and serum creatinine were recorded at baseline and follow-up. Changes in clinical parameters were analyzed using paired Student's t-test.</p> Results <p>The study population comprised 64% males, with most patients aged 41–70 years. Advanced CKD predominated, with 53% and 19% classified as Stage 5 and Stage 4, respectively. Diabetes mellitus (36%) was the most frequent associated condition. Among 198 antihypertensive prescriptions, diuretics (37.8%) and calcium channel blockers (29.0%) were the most commonly prescribed drug classes. Significant reductions were observed in systolic blood pressure (160.13±25.26 to 134.20±19.77 mmHg), diastolic blood pressure (92.63±13.07 to 80.10±10.94 mmHg), and serum creatinine (5.59±3.73 to 4.04±3.20 mg/dL) (all p&lt;0.001).</p> Conclusions <p>Antihypertensive prescribing was largely influenced by advanced CKD, with diuretics and calcium channel blockers predominating. Blood pressure and serum creatinine improved during follow-up; however, these observational findings should not be interpreted as evidence of treatment efficacy. Further multicenter studies with longer follow-up are warranted.</p> Graphical Abstract <p></p>

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Antihypertensive drug utilization and blood pressure outcomes in chronic kidney disease patients: A prospective observational study in a tertiary care hospital

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月21日

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  • Shamama Rehman,
  • Md Abdul Bari,
  • Maryam Fatima,
  • Mirza Yasir Baig,
  • Javed Akhtar Ansari,
  • Mukhtar Ahmad

摘要

Background

Hypertension is highly prevalent in chronic kidney disease (CKD) and contributes to cardiovascular complications and progressive renal dysfunction. Evaluating real-world antihypertensive prescribing patterns may help optimize blood pressure management in this high-risk population.

Methods

A six-month prospective observational study was conducted among 100 adults with CKD and hypertension attending a tertiary-care teaching hospital. Demographic characteristics, CKD stage, associated clinical conditions, antihypertensive prescriptions, blood pressure, and serum creatinine were recorded at baseline and follow-up. Changes in clinical parameters were analyzed using paired Student's t-test.

Results

The study population comprised 64% males, with most patients aged 41–70 years. Advanced CKD predominated, with 53% and 19% classified as Stage 5 and Stage 4, respectively. Diabetes mellitus (36%) was the most frequent associated condition. Among 198 antihypertensive prescriptions, diuretics (37.8%) and calcium channel blockers (29.0%) were the most commonly prescribed drug classes. Significant reductions were observed in systolic blood pressure (160.13±25.26 to 134.20±19.77 mmHg), diastolic blood pressure (92.63±13.07 to 80.10±10.94 mmHg), and serum creatinine (5.59±3.73 to 4.04±3.20 mg/dL) (all p<0.001).

Conclusions

Antihypertensive prescribing was largely influenced by advanced CKD, with diuretics and calcium channel blockers predominating. Blood pressure and serum creatinine improved during follow-up; however, these observational findings should not be interpreted as evidence of treatment efficacy. Further multicenter studies with longer follow-up are warranted.

Graphical Abstract