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Background <p>Ulcerative colitis (UC) is a common health issue worldwide. IL-38 is a cytokine that was verified to have anti-inflammatory role and associated with many inflammatory and immune disorders. We attempted to evaluate serum level of IL-38 and its polymorphism (rs7599662) in patients with ulcerative colitis.</p> Methods <p>Seventy-eight patients with UC and 78 healthy subjects were enrolled. Serum concentration of IL-38 was assessed via ELISA technique. Rs7599662 of IL-38 was investigated using RT-PCR.</p> Results <p>When compared to controls, individuals with UC had considerably higher serum levels of IL-38. Also, the mutant TT genotype of rs7599662 was linked significantly to increased risk of UC (<i>p</i> = 0.009).We revealed the association of IL-38 and its polymorphism with increasing susceptibility to UC indicating their possible participation in pathogenesis of UC and the possibility of using IL-38 as a new biomarker and UC therapy target.</p>

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Association of interleukin-38 and its polymorphism (rs7599662) with ulcerative colitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月16日

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  • Soha M. Hamdy,
  • Alaa Z. Mohamed,
  • Omayma O. Abdelaleem,
  • Ola N. Sayed

摘要

Background

Ulcerative colitis (UC) is a common health issue worldwide. IL-38 is a cytokine that was verified to have anti-inflammatory role and associated with many inflammatory and immune disorders. We attempted to evaluate serum level of IL-38 and its polymorphism (rs7599662) in patients with ulcerative colitis.

Methods

Seventy-eight patients with UC and 78 healthy subjects were enrolled. Serum concentration of IL-38 was assessed via ELISA technique. Rs7599662 of IL-38 was investigated using RT-PCR.

Results

When compared to controls, individuals with UC had considerably higher serum levels of IL-38. Also, the mutant TT genotype of rs7599662 was linked significantly to increased risk of UC (p = 0.009).We revealed the association of IL-38 and its polymorphism with increasing susceptibility to UC indicating their possible participation in pathogenesis of UC and the possibility of using IL-38 as a new biomarker and UC therapy target.