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Background <p>Tuberculosis (TB) remains a major opportunistic infection among people living with HIV (PLHIV). This co-infection leads to atypical presentations and reduces the sensitivity of conventional diagnostic methods. Interferon-gamma-inducible protein 10 (IP-10) has emerged as a potential non-sputum-based biomarker for TB diagnosis. However, there is limited data on the diagnostic performance of this biomarker among the TB/HIV coinfected adult population. Thus, this study evaluated the diagnostic performance of serum IP-10 in detecting TB among the population of TB/HIV co-infected adults and assessed how CD4 + T-cell counts influence its accuracy.</p> Results <p>Of the 56 recruited participants, serum IP-10 showed a sensitivity of 73.7%, specificity of 81.1%, and AUC of 0.777 for TB diagnosis. There was an excellent diagnostic performance among participants with CD4 + &gt; 250 cells/µL (AUC = 0.857) in comparison to those with lower counts (AUC = 0.631). Also, a statistically non-significant inverse negative correlation was observed between IP-10 and CD4 + levels.</p> Conclusion <p>The results of this study highlight the potential utility of IP-10 as a supplementary diagnostic tool in TB/HIV co-infection. However, there is a need for standardisation of cut-off values.</p>

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Performance of interferon-gamma-inducible-protein-10 in the diagnosis of pulmonary tuberculosis among HIV patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月30日

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  • Isa Musa Wasagu,
  • Alakija Kazeem Salami,
  • Ademola Emmanuel Fawibe,
  • Aminu Abbas,
  • Biliaminu Sikiru Abayomi,
  • Yusuff Jameelu-deen Omokunmi,
  • Muhammad Aliyu Makusidi,
  • Adebayo Taiwo Azeez,
  • Nasir Altine Dankiri,
  • Umar Babangida Basihr,
  • Yakubu Egigogo Raji

摘要

Background

Tuberculosis (TB) remains a major opportunistic infection among people living with HIV (PLHIV). This co-infection leads to atypical presentations and reduces the sensitivity of conventional diagnostic methods. Interferon-gamma-inducible protein 10 (IP-10) has emerged as a potential non-sputum-based biomarker for TB diagnosis. However, there is limited data on the diagnostic performance of this biomarker among the TB/HIV coinfected adult population. Thus, this study evaluated the diagnostic performance of serum IP-10 in detecting TB among the population of TB/HIV co-infected adults and assessed how CD4 + T-cell counts influence its accuracy.

Results

Of the 56 recruited participants, serum IP-10 showed a sensitivity of 73.7%, specificity of 81.1%, and AUC of 0.777 for TB diagnosis. There was an excellent diagnostic performance among participants with CD4 + > 250 cells/µL (AUC = 0.857) in comparison to those with lower counts (AUC = 0.631). Also, a statistically non-significant inverse negative correlation was observed between IP-10 and CD4 + levels.

Conclusion

The results of this study highlight the potential utility of IP-10 as a supplementary diagnostic tool in TB/HIV co-infection. However, there is a need for standardisation of cut-off values.