Scholarlink

Introduction <p>This study aims to investigate the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) involving solid organs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). We conducted a retrospective analysis of clinical data from a patient who developed PTLD in solid organs (lungs and liver) after the second allo-HSCT at Beijing GaoBo Boren Hospital.</p> Case presentation <p>A 26-year-old Han Chinese male, employed at a company, was initially diagnosed with T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) and underwent his first haploidentical HSCT (with his father as the donor). Two months post-transplant (+ 2&#xa0;months), he was diagnosed with cytomegalovirus (CMV)/Epstein-Barr virus (EBV) viremia, which resolved following symptomatic treatment. At + 3&#xa0;months post-transplant, he presented with tonsillar swelling, and pathological examination confirmed PTLD. The patient achieved remission following treatment with glucocorticoids combined with four doses of rituximab. At + 6&#xa0;months post-transplant, painful masses appeared in the right neck and right upper arm, and pathological results indicated a relapse of the primary disease (T-ALL/LBL). He was admitted to Beijing GaoBo Boren Hospital and subsequently underwent a second allo-HSCT from an unrelated donor with a full HLA match (10/10). Six months after the second transplant, he developed severe EBV-positive PTLD, initially presenting with recurrent fever and pulmonary nodules, followed by the appearance of rounded low-density lesions in the liver and subcutaneous tissue. No generalized lymphadenopathy was observed. Following pathological confirmation of PTLD, the patient received chemotherapy and achieved complete remission.</p> Conclusion <p>PTLD, a complication of allo-HSCT, may occur exclusively in solid organs without lymph node involvement. PTLD localized to solid organs is prone to misdiagnosis; thus, precise treatment should be initiated only after confirmation by pathological biopsy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Post-transplant lymphoproliferative disorder arising in solid organs (lungs and liver) after hematopoietic stem cell transplantation: a case report

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月16日

查看全文
  • Ruiting Li

摘要

Introduction

This study aims to investigate the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) involving solid organs following allogeneic hematopoietic stem cell transplantation (allo-HSCT). We conducted a retrospective analysis of clinical data from a patient who developed PTLD in solid organs (lungs and liver) after the second allo-HSCT at Beijing GaoBo Boren Hospital.

Case presentation

A 26-year-old Han Chinese male, employed at a company, was initially diagnosed with T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) and underwent his first haploidentical HSCT (with his father as the donor). Two months post-transplant (+ 2 months), he was diagnosed with cytomegalovirus (CMV)/Epstein-Barr virus (EBV) viremia, which resolved following symptomatic treatment. At + 3 months post-transplant, he presented with tonsillar swelling, and pathological examination confirmed PTLD. The patient achieved remission following treatment with glucocorticoids combined with four doses of rituximab. At + 6 months post-transplant, painful masses appeared in the right neck and right upper arm, and pathological results indicated a relapse of the primary disease (T-ALL/LBL). He was admitted to Beijing GaoBo Boren Hospital and subsequently underwent a second allo-HSCT from an unrelated donor with a full HLA match (10/10). Six months after the second transplant, he developed severe EBV-positive PTLD, initially presenting with recurrent fever and pulmonary nodules, followed by the appearance of rounded low-density lesions in the liver and subcutaneous tissue. No generalized lymphadenopathy was observed. Following pathological confirmation of PTLD, the patient received chemotherapy and achieved complete remission.

Conclusion

PTLD, a complication of allo-HSCT, may occur exclusively in solid organs without lymph node involvement. PTLD localized to solid organs is prone to misdiagnosis; thus, precise treatment should be initiated only after confirmation by pathological biopsy.