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<p>Fordyce’s Granules (FG) are natural structures located in the lip vermilion and buccal mucosa. Like the skin’s sebaceous glands, its composition consists mainly of triglycerides. Due to the possibility of fat deposition in unusual places in patients with hyperlipidemia, timely diagnosis and investigation of the relationship between hyperlipidemia and FG is essential. This study aimed to investigate the relationship between the presence of FG in the mouth and obesity. In this study, in several centers, 179 patients referred to oral disease departments were examined for the presence of FG, and the relevant risk factors (age, sex, height, weight, smoking, LDL, HDL, TG) were recorded. Patients suffering from hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, Mesial temporal sclerosis (MTS), heart, vascular, and rheumatological diseases were excluded from the study, then the prepared information was analyzed using SPSS version 23. Totally, 111 patients with Fordyce granules and 68 patients without Fordyce granules were included in the study; 17.1% of Fordyce positive patients and 29.4% of Fordyce negative patients used at least one cigarette daily, and 28.8% of Fordyce positive patients were obese (Body Mass Index (BMI) &gt; 30). Also, 32.4% of Fordyce-negative patients had hyperlipidemia. A statistically significant association was observed between BMI and the presence of Fordyce’s granules. Logistic regression analysis indicated that higher BMI was associated with increased odds of FG occurrence; however, this association does not imply a causal or predictive relationship.</p>

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Relationship between Fordyce’s granules and obesity: a multicenter study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月28日

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  • Zahra Khatibzade,
  • Maryam Jalili Sadrabad,
  • Elham Saberian,
  • Sahar Maleki,
  • Raheb Ghorbani

摘要

Fordyce’s Granules (FG) are natural structures located in the lip vermilion and buccal mucosa. Like the skin’s sebaceous glands, its composition consists mainly of triglycerides. Due to the possibility of fat deposition in unusual places in patients with hyperlipidemia, timely diagnosis and investigation of the relationship between hyperlipidemia and FG is essential. This study aimed to investigate the relationship between the presence of FG in the mouth and obesity. In this study, in several centers, 179 patients referred to oral disease departments were examined for the presence of FG, and the relevant risk factors (age, sex, height, weight, smoking, LDL, HDL, TG) were recorded. Patients suffering from hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, Mesial temporal sclerosis (MTS), heart, vascular, and rheumatological diseases were excluded from the study, then the prepared information was analyzed using SPSS version 23. Totally, 111 patients with Fordyce granules and 68 patients without Fordyce granules were included in the study; 17.1% of Fordyce positive patients and 29.4% of Fordyce negative patients used at least one cigarette daily, and 28.8% of Fordyce positive patients were obese (Body Mass Index (BMI) > 30). Also, 32.4% of Fordyce-negative patients had hyperlipidemia. A statistically significant association was observed between BMI and the presence of Fordyce’s granules. Logistic regression analysis indicated that higher BMI was associated with increased odds of FG occurrence; however, this association does not imply a causal or predictive relationship.