Background <p>Haemoglobinopathies, such as thalassemia and sickle cell anaemia (SCA), are inherited conditions caused by abnormal haemoglobin production. Cardiac problems are among the primary factors contributing to illness and death in these individuals. Cystatin C in humans is a reliable indicator of glomerular filtration rate and may also indicate cardiovascular disease risk, even without chronic renal conditions. We aim to evaluate whether Cystatin C can be used as an early determinant of cardiovascular problems in adult cases with sickle cell anaemia and thalassemia.</p> Methods <p>This study included 41 adults with sickle cell anaemia, 41 patients with B thalassemia, and 41 age and sex-matched controls with clinical and laboratory assessments including complete blood count, Cystatin C, and pro B-type natriuretic peptide, kidney and liver functions. Radiological assessment is done using 2D echocardiography and speckle tracking to detect subtle ventricular dysfunction.</p> Results <p>There was no correlation between Cystatin C level and global longitudinal strain echocardiography in patients with sickle cell anaemia and thalassemia. However, there was a significant variation was observed in the global longitudinal strain of the left ventricle between the sickle cell anaemia cases and thalassemia versus the controls (<i>P</i> &lt; 0.05). Cystatin C levels were higher among the cases when compared to the controls.</p> Conclusion <p>There was no correlation between Cystatin C and the left ventricular global longitudinal strain of sickle cell anaemia and thalassemia.</p>