Scholarlink

Background and objectives <p>Mineral Bone Disturbance (MBD) and Hepatitis C virus (HCV) infection is considered to be the major public health problems in patients with end-stage renal failure on regular hemodialysis. To the best of our knowledge this is the first study aimed to assess the association between HCV infection and MBD on regular hemodialysis patients and to assess the most prominent suspected type of CKD-MBD by clinical, laboratory parameters, and dual-energy x-ray absorptiometry(DEXA).</p> Materials and methods <p>Ninety-four patients with CKD on regular hemodialysis in Assiut University Hospital were classified into 3 groups: (I) HCV negative group (<i>n</i> = 41), (II) HCV positive group (<i>n</i> = 26) who had received treatment (ombitasvir/paritaprevir/ritonavir) (25/150/100), and (III) HCV positive group (<i>n</i> = 27) who had not received treatment with no stigma of chronic liver disease confirmed by the US. Biochemical laboratory assessments were measured according to the standard method: for BUN, creatinine, Ca, phosphorus, and liver functions. Quantitative determination of intact PTH was done by ELISA, HCV infection diagnosis was done by ELISA test to detect Ab against HCV, and PCR for serum HCV RNA. US was performed to exclude manifestations of cirrhosis. Radiological assessment was conducted by dual-energy X-ray absorptiometry (DEXA) on the forearm, femur neck, and lumbar spine.</p> Results <p>In this bone DEXA densitometry-based study, it was noticed that dialysis duration had a significant relation to the grade of BMD. Also, we detected that the highest percentage of cases with osteoporosis and osteoporosis with the possibility of fracture in the arm had a high turnover MBD. Regarding the DEXA findings in the spins, there are significant relations in the majority of cases with osteoporosis, osteoporosis with the possibility of a fracture, and osteopenia with the high turnover MBD. HCV infection has a non-specific influence on the pattern of bone disease in hemodialysis patients. There was a significant increase in the frequency of renal osteodystrophy. High turnover is the most common pattern of CKD-MBD, followed by adynamic bone disease. The forearm was the most affected part of the skeleton.</p> Conclusion <p>HCV has no impact on the pattern of bone disease Dexa scan findings&#xa0;in hemodialysis patients.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

DEXA scan findings and biochemical parameters along the effect of chronic HCV co-infection and viral treatment on the mineral bone disorder in hemodialysis patients:Single center study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月30日

查看全文
  • Nashwa Mostafa A. Azoz,
  • Randa A. ElZohny,
  • Momtaz T. Allam,
  • Marwa A. Dahpy

摘要

Background and objectives

Mineral Bone Disturbance (MBD) and Hepatitis C virus (HCV) infection is considered to be the major public health problems in patients with end-stage renal failure on regular hemodialysis. To the best of our knowledge this is the first study aimed to assess the association between HCV infection and MBD on regular hemodialysis patients and to assess the most prominent suspected type of CKD-MBD by clinical, laboratory parameters, and dual-energy x-ray absorptiometry(DEXA).

Materials and methods

Ninety-four patients with CKD on regular hemodialysis in Assiut University Hospital were classified into 3 groups: (I) HCV negative group (n = 41), (II) HCV positive group (n = 26) who had received treatment (ombitasvir/paritaprevir/ritonavir) (25/150/100), and (III) HCV positive group (n = 27) who had not received treatment with no stigma of chronic liver disease confirmed by the US. Biochemical laboratory assessments were measured according to the standard method: for BUN, creatinine, Ca, phosphorus, and liver functions. Quantitative determination of intact PTH was done by ELISA, HCV infection diagnosis was done by ELISA test to detect Ab against HCV, and PCR for serum HCV RNA. US was performed to exclude manifestations of cirrhosis. Radiological assessment was conducted by dual-energy X-ray absorptiometry (DEXA) on the forearm, femur neck, and lumbar spine.

Results

In this bone DEXA densitometry-based study, it was noticed that dialysis duration had a significant relation to the grade of BMD. Also, we detected that the highest percentage of cases with osteoporosis and osteoporosis with the possibility of fracture in the arm had a high turnover MBD. Regarding the DEXA findings in the spins, there are significant relations in the majority of cases with osteoporosis, osteoporosis with the possibility of a fracture, and osteopenia with the high turnover MBD. HCV infection has a non-specific influence on the pattern of bone disease in hemodialysis patients. There was a significant increase in the frequency of renal osteodystrophy. High turnover is the most common pattern of CKD-MBD, followed by adynamic bone disease. The forearm was the most affected part of the skeleton.

Conclusion

HCV has no impact on the pattern of bone disease Dexa scan findings in hemodialysis patients.

Graphical Abstract