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Background <p>Metabolic dysfunction–associated steatotic liver disease (MASLD) is now the most prevalent chronic liver disease, yet effective lifestyle strategies remain underutilized.</p> Aim <p>This study evaluated the impact of a structured lifestyle intervention on anthropometric, biochemical, and body composition parameters, and assessed the utility of bioelectrical impedance analysis (BIA) in monitoring therapeutic response.</p> Methods <p>We prospectively enrolled 253 MASLD patients (110 males, 43.4%; 143 females, 56.6%). All participants underwent a 12-week lifestyle program combining individualized dietary counseling and structured physical activity. Assessments at baseline and post-intervention included anthropometric indices, BIA-derived body composition, liver enzymes, lipid profile, and non-invasive steatosis/fibrosis scores (HSI, FIB-4). Correlation and regression analyses were performed to identify predictors of BMI reduction.</p> Results <p>After 12&#xa0;weeks, patients achieved significant reductions in body weight, BMI, total fat mass, and visceral fat, alongside increases in fat-free mass and improvements in BIA indices including metabolic age and phase angle. Liver enzymes (ALT, AST) and lipid parameters (total cholesterol, triglycerides, LDL cholesterol) declined significantly, while HDL cholesterol increased. The Hepatic Steatosis Index decreased markedly, whereas FIB-4 values remained unchanged, reflecting the limitation of using a fixed platelet count. Correlation analyses revealed strong positive associations between BMI and BIA-derived fat metrics, and logistic regression identified fat percentage, fat mass, and metabolic age as independent predictors of BMI reduction.</p> Conclusion <p>BIA provides a practical and detailed method for monitoring changes in body composition that accompany improvements in metabolic and hepatic parameters, offering valuable insights into the impact of lifestyle interventions in MASLD.</p>

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Role of bioelectrical impedance in evaluating impacts of lifestyle modifications in patients with MASLD

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月5日

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  • Maha Elsabaawy,
  • Alia Fathlla,
  • Maimona Abelwahed,
  • Samia Loulah,
  • Adel Badr,
  • Nehad Darweesh

摘要

Background

Metabolic dysfunction–associated steatotic liver disease (MASLD) is now the most prevalent chronic liver disease, yet effective lifestyle strategies remain underutilized.

Aim

This study evaluated the impact of a structured lifestyle intervention on anthropometric, biochemical, and body composition parameters, and assessed the utility of bioelectrical impedance analysis (BIA) in monitoring therapeutic response.

Methods

We prospectively enrolled 253 MASLD patients (110 males, 43.4%; 143 females, 56.6%). All participants underwent a 12-week lifestyle program combining individualized dietary counseling and structured physical activity. Assessments at baseline and post-intervention included anthropometric indices, BIA-derived body composition, liver enzymes, lipid profile, and non-invasive steatosis/fibrosis scores (HSI, FIB-4). Correlation and regression analyses were performed to identify predictors of BMI reduction.

Results

After 12 weeks, patients achieved significant reductions in body weight, BMI, total fat mass, and visceral fat, alongside increases in fat-free mass and improvements in BIA indices including metabolic age and phase angle. Liver enzymes (ALT, AST) and lipid parameters (total cholesterol, triglycerides, LDL cholesterol) declined significantly, while HDL cholesterol increased. The Hepatic Steatosis Index decreased markedly, whereas FIB-4 values remained unchanged, reflecting the limitation of using a fixed platelet count. Correlation analyses revealed strong positive associations between BMI and BIA-derived fat metrics, and logistic regression identified fat percentage, fat mass, and metabolic age as independent predictors of BMI reduction.

Conclusion

BIA provides a practical and detailed method for monitoring changes in body composition that accompany improvements in metabolic and hepatic parameters, offering valuable insights into the impact of lifestyle interventions in MASLD.