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Objective <p>This study investigated the effects of time-restricted feeding (TRF) without calorie restriction on renal function in patients with stage 3–5 chronic kidney disease (CKD).</p> Study design and setting <p>An analytical study conducted at Balıkesir University Faculty of Medicine, Türkiye, between December 2021 and December 2022.</p> Methodology <p>Eighty-four CKD patients (18–70&#xa0;years) were divided into a TRF group (<i>n</i> = 42) and a control group (<i>n</i> = 42) with free feeding. Baseline and follow-up measurements at 3 and 6&#xa0;months included height, weight, waist circumference, blood pressure, eGFR, and urine protein-creatinine ratio. Statistical significance was set at <i>p</i> &lt; 0.05.</p> Results <p>Renal function remained stable in the TRF group (<i>p</i> = 0.07), while the control group showed a significant decline (<i>p</i> &lt; 0.01). There was no significant difference between groups in eGFR, urea, and creatinine changes, except for the urine protein–creatinine ratio (<i>p</i> = 0.04). A significant reduction in waist circumference was observed in the TRF group (<i>p</i> &lt; 0.01).</p> Conclusion <p>TRF may serve as a non-pharmacological strategy to preserve renal function and reduce central obesity in moderate to advanced CKD patients not receiving renal replacement therapy. Given the increasing prevalence of CKD, TRF could be a simple, cost-effective addition to current management strategies. Further research is needed to validate its long-term benefits.</p>

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Impact of time-restricted feeding on renal function in advanced chronic kidney disease patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月22日

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  • Ahmet Ürk,
  • Uğur Ergün,
  • Ömer Toprak

摘要

Objective

This study investigated the effects of time-restricted feeding (TRF) without calorie restriction on renal function in patients with stage 3–5 chronic kidney disease (CKD).

Study design and setting

An analytical study conducted at Balıkesir University Faculty of Medicine, Türkiye, between December 2021 and December 2022.

Methodology

Eighty-four CKD patients (18–70 years) were divided into a TRF group (n = 42) and a control group (n = 42) with free feeding. Baseline and follow-up measurements at 3 and 6 months included height, weight, waist circumference, blood pressure, eGFR, and urine protein-creatinine ratio. Statistical significance was set at p < 0.05.

Results

Renal function remained stable in the TRF group (p = 0.07), while the control group showed a significant decline (p < 0.01). There was no significant difference between groups in eGFR, urea, and creatinine changes, except for the urine protein–creatinine ratio (p = 0.04). A significant reduction in waist circumference was observed in the TRF group (p < 0.01).

Conclusion

TRF may serve as a non-pharmacological strategy to preserve renal function and reduce central obesity in moderate to advanced CKD patients not receiving renal replacement therapy. Given the increasing prevalence of CKD, TRF could be a simple, cost-effective addition to current management strategies. Further research is needed to validate its long-term benefits.