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Background <p>T-cadherin, encoded by the <i>CDH13</i> gene, has a significant relationship with atherosclerosis and coronary heart disease (CHD) initiation and progression. Vascular cell adhesion molecule-1 (VCAM-1) plays an essential role in endothelial inflammation. Both T-cadherin and VCAM-1 were associated with the occurrence of ST-elevation myocardial infarction (STEMI).</p> Objective <p>We aimed to find the relationship between <i>CDH13</i> and <i>VCAM-1</i> gene expression in STEMI and to evaluate the ability of their gene expression to predict the prognostic outcome of coronary artery disease (CAD) in acute STEMI.</p> Methods <p>This case-control study enrolled 150 participants: 75 patients with STEMI and 75 healthy controls. A&#xa0;follow-up of patients for 6&#xa0;months was performed. The participants were compared regarding <i>CDH13</i> and <i>VCAM-1</i> gene expression, as well as their 6-month clinical outcome.</p> Results <p><i>CDH13</i> and <i>VCAM-1</i> were significantly elevated in patients with STEMI. Additionally, combined gene expression was significantly superior to single gene expression in predicting the extent of CAD with a Gensini score ≥ 20 at a cut-off value of 5.12 with a sensitivity of 89.5%.</p> Conclusion <p>Combining <i>CDH13 </i>and <i>VCAM-1</i> expression is more valuable than using them individually in predicting the occurrence of major cardiac events (MACE) and predicting the extent of CAD.</p>

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CDH13 and VCAM-1 expressions in predicting the outcome of acute myocardial infarction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月22日

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  • Shaimaa Wageeh,
  • Samia Hussein,
  • Doaa M. Hendawy,
  • Alaa Ramadan Youssuf,
  • AL-Shabrawy M. Abdelnabi,
  • Eman H. Seddik

摘要

Background

T-cadherin, encoded by the CDH13 gene, has a significant relationship with atherosclerosis and coronary heart disease (CHD) initiation and progression. Vascular cell adhesion molecule-1 (VCAM-1) plays an essential role in endothelial inflammation. Both T-cadherin and VCAM-1 were associated with the occurrence of ST-elevation myocardial infarction (STEMI).

Objective

We aimed to find the relationship between CDH13 and VCAM-1 gene expression in STEMI and to evaluate the ability of their gene expression to predict the prognostic outcome of coronary artery disease (CAD) in acute STEMI.

Methods

This case-control study enrolled 150 participants: 75 patients with STEMI and 75 healthy controls. A follow-up of patients for 6 months was performed. The participants were compared regarding CDH13 and VCAM-1 gene expression, as well as their 6-month clinical outcome.

Results

CDH13 and VCAM-1 were significantly elevated in patients with STEMI. Additionally, combined gene expression was significantly superior to single gene expression in predicting the extent of CAD with a Gensini score ≥ 20 at a cut-off value of 5.12 with a sensitivity of 89.5%.

Conclusion

Combining CDH13 and VCAM-1 expression is more valuable than using them individually in predicting the occurrence of major cardiac events (MACE) and predicting the extent of CAD.