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Background <p>Multiple studies indicate that deletion polymorphisms <i>GSTM1</i> and <i>GSTT1</i> within the glutathione S-transferase (GST) gene may be linked with cancer pathogenesis. However, limited research has investigated their association with the development of multiple myeloma (MM). Therefore, we conducted a meta-analysis by&#xa0;pooling data from existing studies to obtain more precise estimates.</p> Methods <p>Relevant literature was systematically searched and screened from various databases. Data from eligible studies were collated and analyzed utilizing Review Manager software by calculating the odds ratios (ORs) and 95% confidence intervals (CIs).</p> Results <p>A total of approximately 1131 participants from 4 studies were included in the analysis. The M1 and T1 deletion polymorphisms showed a significant association with the development of MM. Notably, the <i>GSTM1</i> deletion (<i>OR</i> = 0.66) was associated with a decreased risk, while the <i>GSTT1</i> deletion (<i>OR</i> = 1.60) was linked with an increased risk of MM development.</p> Conclusion <p>In summary, the available evidence suggests that deletion polymorphisms in the GST genes may be associated with MM development. Further investigations are warranted to verify these findings, particularly across diverse ethnic populations.</p>

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Deletion polymorphisms in the glutathione S-transferase genes are associated with the development of multiple myeloma: a meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月10日

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  • Raphael Enrique Tiongco,
  • Arch Raphael Mañalac,
  • Neil David Cayanan,
  • Angela Mae Cuartelon,
  • Michael John Dominguez

摘要

Background

Multiple studies indicate that deletion polymorphisms GSTM1 and GSTT1 within the glutathione S-transferase (GST) gene may be linked with cancer pathogenesis. However, limited research has investigated their association with the development of multiple myeloma (MM). Therefore, we conducted a meta-analysis by pooling data from existing studies to obtain more precise estimates.

Methods

Relevant literature was systematically searched and screened from various databases. Data from eligible studies were collated and analyzed utilizing Review Manager software by calculating the odds ratios (ORs) and 95% confidence intervals (CIs).

Results

A total of approximately 1131 participants from 4 studies were included in the analysis. The M1 and T1 deletion polymorphisms showed a significant association with the development of MM. Notably, the GSTM1 deletion (OR = 0.66) was associated with a decreased risk, while the GSTT1 deletion (OR = 1.60) was linked with an increased risk of MM development.

Conclusion

In summary, the available evidence suggests that deletion polymorphisms in the GST genes may be associated with MM development. Further investigations are warranted to verify these findings, particularly across diverse ethnic populations.