Fatal form of immune reconstitution inflammatory syndrome (IRIS) developed post pneumonia in a solid organ transplant recipient

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2024年2月13日

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Hussain Hussain,
Aya Fadel,
Ekaterina Casmartino,
John Sullivan,
Amanda Fernandes,
Samantha Garcia,
Efrain Garcia

摘要

Background

Immune reconstitution inflammatory syndrome (IRIS) is a complex phenomenon commonly diagnosed with human immunodeficiency virus (HIV). However, rarely, IRIS can develop with other diseases outside of HIV. We are discussing a rare presentation of IRIS following a pseudomonal infection.

Case presentation

We present a 79-year-old Hispanic male who completed a course of cefepime for Pseudomonas aeruginosa hospital-acquired pneumonia. The patient had a 21-year history of solid organ transplant and immunosuppressive therapy, and he developed a fatal form of IRIS post-Pseudomonas aeruginosa.

Conclusions

IRIS may occur in any immunocompromised patient who develops an insidious onset of unexplained clinical and serological deterioration.