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<p>This systematic review focuses on the role of gender in the clinical presentation, treatment response, and long-term outcomes of GBS. A comprehensive search of relevant literature identified studies that specifically investigated gender differences in GBS, with a focus on such subtypes as AIDP. Accordingly, in this review, men exhibited more severe motor symptoms and the axonal subtype of GBS, while in women, sensory disturbances were more common, with a higher risk for a protracted recovery course with persistent symptoms. These results thus indicate that gender does indeed have an important impact on the clinical course of GBS, from initial presentation to treatment outcomes. This review has identified that there is a great need to consider gender in the diagnosis and management of GBS. These differences in presentation and recovery that were observed have again supported the idea for the development of sex-specific clinical guidelines and rehabilitation strategies. This kind of attention to gender disparities from the health provider may provide more personalized care that could improve treatment efficacy overall and thus, by extension, better quality of life for all individuals affected by GBS.</p><p><b>Trial registration</b>: PROSPERO CRD42024598732.</p>

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Gender differences in Guillain-Barré syndrome presentations and outcomes: a systematic review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月3日

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  • Olawale Isreal Oshomoji,
  • Ifeanyi Kalu Oti,
  • Johnson Olasunkanmi Ajiroba,
  • Samuel Oluwaseun Semudara

摘要

This systematic review focuses on the role of gender in the clinical presentation, treatment response, and long-term outcomes of GBS. A comprehensive search of relevant literature identified studies that specifically investigated gender differences in GBS, with a focus on such subtypes as AIDP. Accordingly, in this review, men exhibited more severe motor symptoms and the axonal subtype of GBS, while in women, sensory disturbances were more common, with a higher risk for a protracted recovery course with persistent symptoms. These results thus indicate that gender does indeed have an important impact on the clinical course of GBS, from initial presentation to treatment outcomes. This review has identified that there is a great need to consider gender in the diagnosis and management of GBS. These differences in presentation and recovery that were observed have again supported the idea for the development of sex-specific clinical guidelines and rehabilitation strategies. This kind of attention to gender disparities from the health provider may provide more personalized care that could improve treatment efficacy overall and thus, by extension, better quality of life for all individuals affected by GBS.

Trial registration: PROSPERO CRD42024598732.