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Background <p>Acute cellular rejection (ACR) is a life-threatening event that mostly occurs in the first month after liver transplantation. Genetic polymorphisms in the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha (NFKBIA) and protein tyrosine phosphatase non-receptor (PTPN22) genes are linked to organ rejection. Our study aimed to assess whether NFKBIA (rs696;126 G/A) and PTPN22 (rs2476601;1858G/A) gene polymorphisms are associated with ACR in liver transplant (LT) Egyptian recipients.</p> Methods <p>Our study was observational prospective cohort study. The study was conducted on LT Egyptian recipients on immunosuppression to investigate the influence of NFKBIA (rs696;126 G/A) and PTPN22 (rs2476601;1858G/A) gene polymorphism on the incidence of ACR after liver transplantation.</p> Results <p>Our study enrolled ninety-eight patients. Twenty-nine patients experienced ACR, while 69 patients showed no ACR. The homozygous allele (GG) of the PTPN22 (rs2476601;1858G/A) gene had lower rejection episodes when compared with heterozygous genotypes. Higher trough levels of tacrolimus and cyclosporin have shown a lower risk of ACR (<i>p</i> = 0.044 and <i>p</i> = 0.008), respectively.</p> Conclusion <p>Trough levels of immunosuppressant are not the only predictor for ACR but also genetic polymorphism plays a role.</p> Graphical abstract <p></p>

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Role of NFKBIA and PTPN22 genes polymorphism in acute rejection susceptibility after living donor liver transplantation in Egyptian patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月8日

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  • Kareem A. Abdel Aziz,
  • Manar Salah,
  • Sara Mohamed Abdel Motaleb,
  • Radwa Samir Hagag,
  • Monda M. M. Badawy,
  • Gehan R. Abdel‑Hamid,
  • Nermeen M. ElBakary,
  • Safaa Ragab Askar

摘要

Background

Acute cellular rejection (ACR) is a life-threatening event that mostly occurs in the first month after liver transplantation. Genetic polymorphisms in the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha (NFKBIA) and protein tyrosine phosphatase non-receptor (PTPN22) genes are linked to organ rejection. Our study aimed to assess whether NFKBIA (rs696;126 G/A) and PTPN22 (rs2476601;1858G/A) gene polymorphisms are associated with ACR in liver transplant (LT) Egyptian recipients.

Methods

Our study was observational prospective cohort study. The study was conducted on LT Egyptian recipients on immunosuppression to investigate the influence of NFKBIA (rs696;126 G/A) and PTPN22 (rs2476601;1858G/A) gene polymorphism on the incidence of ACR after liver transplantation.

Results

Our study enrolled ninety-eight patients. Twenty-nine patients experienced ACR, while 69 patients showed no ACR. The homozygous allele (GG) of the PTPN22 (rs2476601;1858G/A) gene had lower rejection episodes when compared with heterozygous genotypes. Higher trough levels of tacrolimus and cyclosporin have shown a lower risk of ACR (p = 0.044 and p = 0.008), respectively.

Conclusion

Trough levels of immunosuppressant are not the only predictor for ACR but also genetic polymorphism plays a role.

Graphical abstract