The evidence-based new vista to wane the utilization of antimicrobials in UTIs

In recent years, antibiotic resistance rates have become a global concern for clinicians to combat the pathogenic bacteria associated with UTIs. The objective of this current paper is to explore the evidence-based use of natural products as an alternative strategy to reduce the recurrence rates among different UTI patient populations such as pregnant women, postmenopause women, and children.

Commonly used non-antimicrobial products to treat and prevent UTIs include vaginal estrogen, cranberry, probiotics, D-mannose, hyaluronic acid (HA), Chinese herbal medicine, and ascorbic acid. Literature supports the safety and effectiveness of utilizing these products in different UTI patients to a great extent. The strongest recommendation was given to the utilization of vaginal estrogen replacement therapy in postmenopausal females to prevent rUTI.

We believe our research is the first to provide evidence-based clinical practice guidelines and insight into UTI management using non-antimicrobial drugs in different populations. Our findings can guide future research on the reduction of antimicrobial misuse and preventing antimicrobial resistance.