A chalcone derivative SBD-2 exerts anticancer effects in human colorectal cancer cells

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2024年8月6日

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Bowen Zheng,
Wanjun Lin,
Na Zhang,
Xiaoming Huang,
Jingjing Du,
Yunfu Shen,
Junhe Chen,
Qianyu Lin,
Zhuya Yang,
Wenzhe Ma

摘要

Background

In this study, the potential anticancer activity and mechanism of action of SBD-2, a chalcone isolated from Shuteria involucrata, was investigated in colorectal cancer (CRC) cells.

Results

SBD-2 inhibited the proliferation of Caco-2 cells in a dose-dependent manner. It elicited the cells arrested in the G2/M phase and induced apoptosis. Mechanistically, SBD-2 inhibited Akt phosphorylation, which suppressed the ani-apoptotic protein Bcl-2 and cell cycle regulator Cyclin B1, leading to apoptosis ad cycle arrest, respectively.

Conclusions

The presented chalcone compound SBD-2 from Shuteria involucrata induced apoptosis and cell cycle arrest through inhibiting Akt pathway, highlighting the possibility to develop as a new agent for CRC treatment.