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Background <p>A high-fat diet (HFD) can influence the morphology structure, and function of the brain, resulting in cognitive decline and neural tissue damage. The dried mature seeds of <i>Raphanus sativus</i> L. (<i>Semen Raphani</i>), have been proven to improve metabolic disorders and have neuroprotective benefits</p> Methods <p>The model of metabolic cognitive impairment was established in rats. Subsequently, interventions were conducted using different doses of <i>Semen Raphani</i>.</p> Results <p>The results showed that <i>Semen Raphani</i> could significantly reduce the weight gain of rats (<i>p</i> &lt; 0.05) and reverse the learning and memory abilities of rats (<i>p</i> &lt; 0.05).</p> Conclusion <p><i>Semen Raphani</i> (RS) exert a beneficial effect on HFD-mediated metabolic damage to the brain. Oxidative stress, neuroinflammation, and mitochondrial function represent potential mechanisms through which <i>Semen Raphani</i> ameliorates high-fat diet-induced cognitive impairment.</p> Clinical trial number <p>Not applicable.</p> Graphical Abstract <p></p>

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Raphanus sativus L. (Semen Raphani) seeds ameliorates cognitive dysfunction induced by high-fat diet in rats by affecting mitochondrial function and brain morphological integrity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月17日

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  • Lingxin Liu,
  • Xiaowen Sun,
  • Xianchun Zeng,
  • Yi Zhu

摘要

Background

A high-fat diet (HFD) can influence the morphology structure, and function of the brain, resulting in cognitive decline and neural tissue damage. The dried mature seeds of Raphanus sativus L. (Semen Raphani), have been proven to improve metabolic disorders and have neuroprotective benefits

Methods

The model of metabolic cognitive impairment was established in rats. Subsequently, interventions were conducted using different doses of Semen Raphani.

Results

The results showed that Semen Raphani could significantly reduce the weight gain of rats (p < 0.05) and reverse the learning and memory abilities of rats (p < 0.05).

Conclusion

Semen Raphani (RS) exert a beneficial effect on HFD-mediated metabolic damage to the brain. Oxidative stress, neuroinflammation, and mitochondrial function represent potential mechanisms through which Semen Raphani ameliorates high-fat diet-induced cognitive impairment.

Clinical trial number

Not applicable.

Graphical Abstract