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Background <p>The immunosuppressive effects of glucocorticoids on T-cells are caused by the down-regulation of Annexin-A1, a protein essential for T-cell activation and adaptive immunity. Therefore, it is interesting to explore the impact of date palm <i>(Phoenix dactylifera L.)</i> fruits and/or <i>Saccharomyces cerevisiae</i> (<i>S. cerevisiae</i>) probiotics on Annexin-A1 expression in rabbit spleen.</p> Methods <p>White <i>New Zealand</i> male rabbits were divided into five groups: control, Dexamethasone (DXM), Dexamethasone plus Date palm (DXM + Date), Dexamethasone plus <i>Saccharomyces cerevisiae</i> (DXM + <i>S. cerevisiae</i>), and Dexamethasone plus Date palm plus <i>Saccharomyces cerevisiae</i> (DXM + Date + <i>S. cerevisiae</i>) treated groups.</p> Results <p>Dexamethasone caused oxidative stress and immunological suppression, as evidenced by significant increases in catalase and Malondialdehyde (MDA), as well as a notable depletion of reduced Glutathione (GSH) in splenic tissues. The study reported a significant decrease in Annexin-A1 expression, as well as decreases in Interferon gamma (IF-γ), Cyclooxygenase 2 (COX-2), and Interleukin 6 (IL-6) expressions in splenic tissue. However, serum immunoglobulin G (IgG) and immunoglobulin M (IgM) levels are non-significantly decreased. Conversely, co-treatments of DXM-treated rabbits with date palm and/or <i>S. cerevisiae</i> restored nearly all biochemical changes to normal.</p> Conclusion <p>Date palm, alone or in combination with <i>S. cerevisiae</i>, can increase splenic Annexin-A1 expression. Furthermore, the data revealed that date palm may have a more immune-stimulant impact than <i>S. cerevisiae</i> in rabbits, as well as a synergistic effect of both. These treatments present a novel way to increase Annexin-A1 signaling as a potential technique for managing immunological deficits.</p>

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Immunomodulatory effects of Phoenix dactylifera and Saccharomyces cerevisiae probiotics via activation of splenic Annexin-A1 expression in rabbits

  • 期刊论文

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  • 发表日期：

    2026年7月22日

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  • Eman Taha Mohammed,
  • Mohamed A. Kandeil,
  • Omima I. Gad,
  • Asmaa M. Abd-Elrahman,
  • Emtnan M. Hassan

摘要

Background

The immunosuppressive effects of glucocorticoids on T-cells are caused by the down-regulation of Annexin-A1, a protein essential for T-cell activation and adaptive immunity. Therefore, it is interesting to explore the impact of date palm (Phoenix dactylifera L.) fruits and/or Saccharomyces cerevisiae (S. cerevisiae) probiotics on Annexin-A1 expression in rabbit spleen.

Methods

White New Zealand male rabbits were divided into five groups: control, Dexamethasone (DXM), Dexamethasone plus Date palm (DXM + Date), Dexamethasone plus Saccharomyces cerevisiae (DXM + S. cerevisiae), and Dexamethasone plus Date palm plus Saccharomyces cerevisiae (DXM + Date + S. cerevisiae) treated groups.

Results

Dexamethasone caused oxidative stress and immunological suppression, as evidenced by significant increases in catalase and Malondialdehyde (MDA), as well as a notable depletion of reduced Glutathione (GSH) in splenic tissues. The study reported a significant decrease in Annexin-A1 expression, as well as decreases in Interferon gamma (IF-γ), Cyclooxygenase 2 (COX-2), and Interleukin 6 (IL-6) expressions in splenic tissue. However, serum immunoglobulin G (IgG) and immunoglobulin M (IgM) levels are non-significantly decreased. Conversely, co-treatments of DXM-treated rabbits with date palm and/or S. cerevisiae restored nearly all biochemical changes to normal.

Conclusion

Date palm, alone or in combination with S. cerevisiae, can increase splenic Annexin-A1 expression. Furthermore, the data revealed that date palm may have a more immune-stimulant impact than S. cerevisiae in rabbits, as well as a synergistic effect of both. These treatments present a novel way to increase Annexin-A1 signaling as a potential technique for managing immunological deficits.