Background <p>Over the past two decades, research interest in endoplasmic reticulum stress in glioma has gradually increased, and the number of related publications has shown distinct phases of growth. Clarifying the global status, key hotspots, and future trends of endoplasmic reticulum stress research in glioma is of great significance for advancing theoretical understanding and clinical translation in this field. This study aims to systematically analyze publications related to endoplasmic reticulum stress in glioma through bibliometric analysis, to outline the current research status and explore potential emerging directions.</p> Methods <p>This study analyzed 414 publications on endoplasmic reticulum (ER) stress in gliomas published between 2000 and 2024. Bibliometric tools including CiteSpace, VOSviewer, and Microsoft Office Excel were used to assess research output trends, national/regional cooperation networks, core institutional contributions, journal distributions, core author characteristics, and keyword hotspot evolution.</p> Results <p>Global research output on ER stress in gliomas showed distinct growth stages. The United States, China, the United Kingdom, France, and Spain were core countries, forming a collaborative network led by North America, Western Europe, and East Asia. Inserm served as an international cooperation hub, while the Chinese Academy of Sciences and the German Cancer Research Center demonstrated extensive research experience and significant academic influence. Chen Thomas C. was a highly productive and influential author, and Schoenthal Axel H. and others advanced the field through high-quality work. <i>International Journal of Molecular Sciences</i> and <i>Nature Communications</i> performed prominently in recent years. The research focus shifted from basic modeling and mechanistic exploration in the early 2000s toward translational research after 2019. Currently, temozolomide and selenium nanoparticles represent topics of rapidly growing research attention, reflecting increasing interest in targeted modulation of endoplasmic reticulum stress.</p> Conclusions <p>This bibliometric analysis systematically maps publication patterns, collaboration structures, and keyword evolution of ER stress in glioma from 2000 to 2024. The field has shifted toward translational research, with temozolomide and selenium nanoparticles identified as emerging research topics. These findings reflect research trends rather than validating biological mechanisms or clinical strategies. Cross-disease knowledge integration may guide future studies.</p> Clinical trial number <p>Not applicable.</p>