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Background <p>The main objective of this research was to develop a novel gastroretentive formulation for Cefditoren pivoxil, an insoluble and poorly permeable drug. Floating and drug release characteristics of tablets formulated with pure Cefditoren pivoxil were compared with the same of formulations loaded with nanosponges (NS) form of drug.</p> Results <p>Test results related to physicochemical properties of all prepared tablets were observed to be in compliance with standards. More floating lag time (6 to 12 minutes) and less log time (less than 12 hours) have been resulted from the formulations with pure form of drug (F1 to F4), whereas, vice-versa (93 to 6 minutes lag time &amp; more than 12 hours log time) was found with NS based dosage forms (F5 to F8). An evaluation test for in-vitro drug release was performed for all the dosage units and more controlled release pattern with diffusion mechanism was seen from tablets loaded with NS. F7 with a combination of NS form of drug and Guar gum in 1:1 ratio has shown best buoyancy (2.1±0.22 minutes lag-time and &gt;12 hours log-time) and more controlled drug release (99.77±1.13%) among all 8 tablet compositions.</p> Conclusions <p>The importance and need for entrapment of an insoluble, less permeable drug to obtain the fruitful buoyant and drug release properties from Gastroretentive tablet dosage forms has been witnessed by all the observed results.</p>

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Formulation and Evaluation of Buoyant tablets loaded with Nanosponges containing entrapped Cefditoren pivoxil

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月22日

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  • Naga Raju Kandukoori,
  • Gundegani Saikumar,
  • Deepika B.,
  • N. Saritha Devi,
  • Kiran Thadkala

摘要

Background

The main objective of this research was to develop a novel gastroretentive formulation for Cefditoren pivoxil, an insoluble and poorly permeable drug. Floating and drug release characteristics of tablets formulated with pure Cefditoren pivoxil were compared with the same of formulations loaded with nanosponges (NS) form of drug.

Results

Test results related to physicochemical properties of all prepared tablets were observed to be in compliance with standards. More floating lag time (6 to 12 minutes) and less log time (less than 12 hours) have been resulted from the formulations with pure form of drug (F1 to F4), whereas, vice-versa (93 to 6 minutes lag time & more than 12 hours log time) was found with NS based dosage forms (F5 to F8). An evaluation test for in-vitro drug release was performed for all the dosage units and more controlled release pattern with diffusion mechanism was seen from tablets loaded with NS. F7 with a combination of NS form of drug and Guar gum in 1:1 ratio has shown best buoyancy (2.1±0.22 minutes lag-time and >12 hours log-time) and more controlled drug release (99.77±1.13%) among all 8 tablet compositions.

Conclusions

The importance and need for entrapment of an insoluble, less permeable drug to obtain the fruitful buoyant and drug release properties from Gastroretentive tablet dosage forms has been witnessed by all the observed results.