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Background and objectives <p>Curcumin (Cur) and curcumin nanoparticles (Cur-NPs) have demonstrated protective effects against nephrotoxicity by reducing oxidative stress, inflammation, and cellular damage. This study aimed to evaluate and compare the efficacy of Cur-NPs with conventional Cur in a gentamicin (GNT)-induced nephrotoxicity model in albino rats.</p> Materials and methods <p>Twenty-four adult male albino rats were divided into four groups. Group I: control; Group II (Nephrotoxicity): using 100&#xa0;mg/kg of GNT intraperitonially once daily for 10 consecutive days; Group III (GNT + Cur): received GNT as in group II, then oral Cur 100&#xa0;mg/kg/daily for 14&#xa0;days; and Group IV (GNT + Cur-NPs): received GNT as in group II, then oral Cur-NPs 100&#xa0;mg/kg daily for 14&#xa0;days. Serum urea &amp; creatinine were assessed on day 0, 10 and 24 of the experiment. The right kidneys were collected and processed for Hematoxylin and Eosin (H&amp;E), Periodic acid Schiff (PAS) and immunohistochemical staining for LC3B. The left kidneys were processed for transmission electron microscopic examination.</p> Results <p>Gentamicin group illustrated severe damage of Malpighian renal corpuscles and renal tubules, accompanied by a significant increase in serum urea and creatinine levels (<i>p</i> &lt; 0.05). Treatment with Cur-NPs significantly reduced serum urea and creatinine (<i>p</i> &lt; 0.05) and more effectively restored renal histoarchitecture compared to Cur.</p> Conclusion <p>Cur-NPs revealed a profound improvement in the kidney structure in comparison with Cur in a rat model of nephrotoxicity.</p>

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Protective effect of curcumin nanoparticles versus curcumin on gentamicin-induced nephrotoxicity in albino rats: histological and immunohistochemical study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月11日

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  • Rokia Mohamad Hassan,
  • Asmaa Ahmed El-Shafei,
  • Dina Hisham Mohamed

摘要

Background and objectives

Curcumin (Cur) and curcumin nanoparticles (Cur-NPs) have demonstrated protective effects against nephrotoxicity by reducing oxidative stress, inflammation, and cellular damage. This study aimed to evaluate and compare the efficacy of Cur-NPs with conventional Cur in a gentamicin (GNT)-induced nephrotoxicity model in albino rats.

Materials and methods

Twenty-four adult male albino rats were divided into four groups. Group I: control; Group II (Nephrotoxicity): using 100 mg/kg of GNT intraperitonially once daily for 10 consecutive days; Group III (GNT + Cur): received GNT as in group II, then oral Cur 100 mg/kg/daily for 14 days; and Group IV (GNT + Cur-NPs): received GNT as in group II, then oral Cur-NPs 100 mg/kg daily for 14 days. Serum urea & creatinine were assessed on day 0, 10 and 24 of the experiment. The right kidneys were collected and processed for Hematoxylin and Eosin (H&E), Periodic acid Schiff (PAS) and immunohistochemical staining for LC3B. The left kidneys were processed for transmission electron microscopic examination.

Results

Gentamicin group illustrated severe damage of Malpighian renal corpuscles and renal tubules, accompanied by a significant increase in serum urea and creatinine levels (p < 0.05). Treatment with Cur-NPs significantly reduced serum urea and creatinine (p < 0.05) and more effectively restored renal histoarchitecture compared to Cur.

Conclusion

Cur-NPs revealed a profound improvement in the kidney structure in comparison with Cur in a rat model of nephrotoxicity.