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Background <p>Acute liver failure (ALF) is a rare, life-threatening syndrome defined by acute liver injury, coagulopathy, and encephalopathy in patients without preexisting liver disease. Amiodarone, a class III antiarrhythmic, is associated with multisystem toxicity, but ALF has been reported only in a few cases.</p> Case presentation <p>A 50-year-old man presented to the emergency department with atrial fibrillation with rapid ventricular response. He was treated with intravenous (IV) amiodarone (300&#xa0;mg bolus, then 900&#xa0;mg/24&#xa0;h infusion). Twelve hours later, he developed encephalopathy and laboratory evidence of ALF. Viral, autoimmune, and metabolic causes were excluded, and abdominal imaging was unremarkable. Amiodarone was discontinued, and he was admitted to the intensive care unit. Rate control was achieved with IV verapamil and improved within 72&#xa0;h. The patient was discharged on day 6 with stable clinical status.</p> Conclusions <p>ALF after IV amiodarone is an uncommon but potentially fatal complication.</p>

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Acute liver failure after intravenous amiodarone: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月19日

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  • Gustavo Abraham Canales-Azcona,
  • Abraham Castellanos-Maldonado,
  • Héctor Raúl Ibarra-Sifuentes,
  • Daniel Hernández-Bocanegra,
  • Norma Georgina Rodríguez-Bustos,
  • Abraham Jesús Navarrete-Ortiz,
  • Antonio Elías García-Gálvez,
  • Sergio Martínez-Arroyo

摘要

Background

Acute liver failure (ALF) is a rare, life-threatening syndrome defined by acute liver injury, coagulopathy, and encephalopathy in patients without preexisting liver disease. Amiodarone, a class III antiarrhythmic, is associated with multisystem toxicity, but ALF has been reported only in a few cases.

Case presentation

A 50-year-old man presented to the emergency department with atrial fibrillation with rapid ventricular response. He was treated with intravenous (IV) amiodarone (300 mg bolus, then 900 mg/24 h infusion). Twelve hours later, he developed encephalopathy and laboratory evidence of ALF. Viral, autoimmune, and metabolic causes were excluded, and abdominal imaging was unremarkable. Amiodarone was discontinued, and he was admitted to the intensive care unit. Rate control was achieved with IV verapamil and improved within 72 h. The patient was discharged on day 6 with stable clinical status.

Conclusions

ALF after IV amiodarone is an uncommon but potentially fatal complication.