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Background <p>Malnutrition is a common and serious complication in patients with liver cirrhosis, contributing to increased morbidity and mortality. Despite the high prevalence of nutritional deficits in this population, dietary guidance remains inconsistent across clinical practice.</p> Objective <p>This review aims to synthesize current evidence and nutritional society guidelines to clarify optimal dietary practices for patients with cirrhosis and translate these findings into actionable, patient-centered dietary recommendations.</p> Methods <p>We reviewed and integrated data from over 50 primary studies and position statements from ESPEN, AASLD, and INASL. Each macronutrient category was examined with respect to its impact on outcomes such as hepatic encephalopathy, sarcopenia, hospitalization risk, and survival. Where guidelines lacked clarity, primary literature was used to fill critical gaps. Practical recommendations were consolidated into a summary table and accompanying educational infographic for patients.</p> Results <p>Optimal protein intake for cirrhotic patients is 1.2–1.5&#xa0;g/kg/day, including animal protein if plant-based options are poorly tolerated. Long-term BCAA supplementation improves nitrogen balance and may reduce cirrhosis-related complications. Carbohydrates should comprise 50–60% of total caloric intake, with late-evening snacks providing 50–100&#xa0;g of carbohydrates shown to reduce overnight catabolism, preserve muscle mass, and improve quality of life. Whole grains, fruits, vegetables, and fermented dairy products enhance gut microbial diversity, which is associated with reduced hospitalization rates. Sodium should only be restricted in patients with ascites; routine restriction in stable patients may lead to malnutrition. Micronutrient supplementation, including thiamine, zinc, and vitamin D, should be targeted based on clinical risk factors and lab parameters.</p> Conclusion <p>This review translates current evidence and clinical guidelines into a practical, food-based framework to support nutritional counseling for patients with liver cirrhosis. The findings are summarized in a visual patient handout to help bridge the gap between evidence-based nutrition and real-world dietary behavior.</p>

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Nutritional interventions in liver cirrhosis: dietary management for improved outcomes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月10日

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  • Robert Ades,
  • Heather Archer-Dyer

摘要

Background

Malnutrition is a common and serious complication in patients with liver cirrhosis, contributing to increased morbidity and mortality. Despite the high prevalence of nutritional deficits in this population, dietary guidance remains inconsistent across clinical practice.

Objective

This review aims to synthesize current evidence and nutritional society guidelines to clarify optimal dietary practices for patients with cirrhosis and translate these findings into actionable, patient-centered dietary recommendations.

Methods

We reviewed and integrated data from over 50 primary studies and position statements from ESPEN, AASLD, and INASL. Each macronutrient category was examined with respect to its impact on outcomes such as hepatic encephalopathy, sarcopenia, hospitalization risk, and survival. Where guidelines lacked clarity, primary literature was used to fill critical gaps. Practical recommendations were consolidated into a summary table and accompanying educational infographic for patients.

Results

Optimal protein intake for cirrhotic patients is 1.2–1.5 g/kg/day, including animal protein if plant-based options are poorly tolerated. Long-term BCAA supplementation improves nitrogen balance and may reduce cirrhosis-related complications. Carbohydrates should comprise 50–60% of total caloric intake, with late-evening snacks providing 50–100 g of carbohydrates shown to reduce overnight catabolism, preserve muscle mass, and improve quality of life. Whole grains, fruits, vegetables, and fermented dairy products enhance gut microbial diversity, which is associated with reduced hospitalization rates. Sodium should only be restricted in patients with ascites; routine restriction in stable patients may lead to malnutrition. Micronutrient supplementation, including thiamine, zinc, and vitamin D, should be targeted based on clinical risk factors and lab parameters.

Conclusion

This review translates current evidence and clinical guidelines into a practical, food-based framework to support nutritional counseling for patients with liver cirrhosis. The findings are summarized in a visual patient handout to help bridge the gap between evidence-based nutrition and real-world dietary behavior.