Scholarlink

Background <p>Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic liver disorder that significantly elevates the risk of comorbidities such as diabetes mellitus, dyslipidemia, hypertension, and complications from parenteral nutrition. Characterized by abnormal triglyceride accumulation in hepatocytes due to disrupted hepatic lipid metabolism, NAFLD affects approximately 24% of the global adult population. The highest regional prevalence has been reported in the Middle East (31.79%), followed by North America (30.45%), Europe (23.71%), and Africa (13.48%). Owing to its widespread incidence, diagnostic complexity, multifactorial pathogenesis, and absence of approved treatments, NAFLD presents a considerable clinical challenge.</p> Main body <p>This review outlines current insights into the disease’s pathophysiology and delves into the key mechanisms involved, including oxidative stress, lipid dysregulation, and insulin resistance. It also highlights the therapeutic potential of natural compounds targeting these pathways.</p> Conclusion <p>The study further explores medicinal plants and their bioactive constituents, emphasizing their influence on hepatic lipid metabolism and regulation of critical transcription factors. These findings suggest a promising role for phytochemicals in the management and possible mitigation of NAFLD progression.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Role of natural compounds in non-alcoholic fatty liver diseases (NAFLD): a mechanistic approach

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月26日

查看全文
  • Pranay Wal,
  • Shweta Yadav,
  • Sajal Kumar Jha,
  • Akanksha Singh,
  • B. Bhargavi,
  • Rekha Shivaram,
  • Mohd Imran,
  • Namra Aziz

摘要

Background

Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic liver disorder that significantly elevates the risk of comorbidities such as diabetes mellitus, dyslipidemia, hypertension, and complications from parenteral nutrition. Characterized by abnormal triglyceride accumulation in hepatocytes due to disrupted hepatic lipid metabolism, NAFLD affects approximately 24% of the global adult population. The highest regional prevalence has been reported in the Middle East (31.79%), followed by North America (30.45%), Europe (23.71%), and Africa (13.48%). Owing to its widespread incidence, diagnostic complexity, multifactorial pathogenesis, and absence of approved treatments, NAFLD presents a considerable clinical challenge.

Main body

This review outlines current insights into the disease’s pathophysiology and delves into the key mechanisms involved, including oxidative stress, lipid dysregulation, and insulin resistance. It also highlights the therapeutic potential of natural compounds targeting these pathways.

Conclusion

The study further explores medicinal plants and their bioactive constituents, emphasizing their influence on hepatic lipid metabolism and regulation of critical transcription factors. These findings suggest a promising role for phytochemicals in the management and possible mitigation of NAFLD progression.

Graphical Abstract