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Aim <p>To analyze body composition using bioelectrical impedance analysis (BIA) and identify potential predictors of significant fibrosis by comparing clinical, laboratory, and BIA parameters.</p> Methods <p>A total of 146 patients with NAFLD were enrolled, of whom 69 had significant fibrosis (F2 or higher, Group A), while 77 had no significant fibrosis (F0-F1, Group B). Additionally, 35 healthy controls were included (Group C). All participants underwent detailed clinical evaluation, FibroScan®, and BIA using a four-electrode machine.</p> Results <p>Patients in Group A were older (56.7 ± 10.8 vs. 42 ± 11.6&#xa0;years) and had a higher prevalence of diabetes mellitus (63.8% vs. 35.1%) and hypertension (47.8% vs. 28.6%) compared to Group B. They also had a significantly higher visceral adipose tissue (VAT) percentage (18 ± 6% vs. 15 ± 7%) and body water content (53 ± 3% vs. 51 ± 3%). Conversely, patients in Group B had a higher body mass index (BMI) (31.3 ± 5.3 vs. 28.9 ± 4.9&#xa0;kg/m<sup>2</sup>), total body fat percentage (32 ± 6.4% vs. 28 ± 6%), subcutaneous adipose tissue (SAT) percentage (28 ± 6% vs. 22 ± 7%), and bone mass (2.9 ± 0.7 vs. 2.6 ± 0.7&#xa0;kg). Skeletal muscle percentage was slightly higher in Group B but not statistically significant (35 ± 6% vs. 33 ± 6%). Group C (controls) had significantly lower total body fat (24 ± 7%), VAT (9 ± 3%), and SAT (18 ± 7%) while having a higher muscle mass percentage (38 ± 4%) and bone mass (2.9 ± 0.38&#xa0;kg) compared to both Groups A and B. Laboratory differences between Group A and B included significantly lower hemoglobin (11.65 ± 2.09 vs. 12.87 ± 1.67&#xa0;g/dL), platelet count (168 ± 66 vs. 282 ± 72 /mm<sup>3</sup>), total protein (6.87 ± 0.82 vs. 7.60 ± 0.48&#xa0;g/dL), and albumin levels (3.51 ± 0.55 vs. 3.94 ± 0.32&#xa0;g/dL) in Group A. Higher bilirubin (1.25 ± 1.04 vs. 0.82 ± 0.48&#xa0;mg/dL) and HbA1c levels (6.87 ± 1.73 vs. 6.23 ± 1.17%) were also observed in Group A.</p> Conclusion <p>NAFLD patients with significant fibrosis tend to be older, more likely to have diabetes and hypertension, and exhibit higher VAT and body water content. In contrast, those without significant fibrosis have higher BMI, total body fat percentage, SAT, muscle mass, and bone mass. These findings suggest that body composition parameters may play a role in the progression of fibrosis in NAFLD.</p> Graphical Abstract <p></p>

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Body composition and changes with significant fibrosis in NAFLD: a cross-sectional analysis from a tertiary care center in Western India

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  • 发表日期：

    2025年7月22日

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  • Abhishek Yadav,
  • Sunil Dadhich,
  • Vivek Saini,
  • Rajendra Bhati,
  • Bobby Mitrolia

摘要

Aim

To analyze body composition using bioelectrical impedance analysis (BIA) and identify potential predictors of significant fibrosis by comparing clinical, laboratory, and BIA parameters.

Methods

A total of 146 patients with NAFLD were enrolled, of whom 69 had significant fibrosis (F2 or higher, Group A), while 77 had no significant fibrosis (F0-F1, Group B). Additionally, 35 healthy controls were included (Group C). All participants underwent detailed clinical evaluation, FibroScan®, and BIA using a four-electrode machine.

Results

Patients in Group A were older (56.7 ± 10.8 vs. 42 ± 11.6 years) and had a higher prevalence of diabetes mellitus (63.8% vs. 35.1%) and hypertension (47.8% vs. 28.6%) compared to Group B. They also had a significantly higher visceral adipose tissue (VAT) percentage (18 ± 6% vs. 15 ± 7%) and body water content (53 ± 3% vs. 51 ± 3%). Conversely, patients in Group B had a higher body mass index (BMI) (31.3 ± 5.3 vs. 28.9 ± 4.9 kg/m2), total body fat percentage (32 ± 6.4% vs. 28 ± 6%), subcutaneous adipose tissue (SAT) percentage (28 ± 6% vs. 22 ± 7%), and bone mass (2.9 ± 0.7 vs. 2.6 ± 0.7 kg). Skeletal muscle percentage was slightly higher in Group B but not statistically significant (35 ± 6% vs. 33 ± 6%). Group C (controls) had significantly lower total body fat (24 ± 7%), VAT (9 ± 3%), and SAT (18 ± 7%) while having a higher muscle mass percentage (38 ± 4%) and bone mass (2.9 ± 0.38 kg) compared to both Groups A and B. Laboratory differences between Group A and B included significantly lower hemoglobin (11.65 ± 2.09 vs. 12.87 ± 1.67 g/dL), platelet count (168 ± 66 vs. 282 ± 72 /mm3), total protein (6.87 ± 0.82 vs. 7.60 ± 0.48 g/dL), and albumin levels (3.51 ± 0.55 vs. 3.94 ± 0.32 g/dL) in Group A. Higher bilirubin (1.25 ± 1.04 vs. 0.82 ± 0.48 mg/dL) and HbA1c levels (6.87 ± 1.73 vs. 6.23 ± 1.17%) were also observed in Group A.

Conclusion

NAFLD patients with significant fibrosis tend to be older, more likely to have diabetes and hypertension, and exhibit higher VAT and body water content. In contrast, those without significant fibrosis have higher BMI, total body fat percentage, SAT, muscle mass, and bone mass. These findings suggest that body composition parameters may play a role in the progression of fibrosis in NAFLD.

Graphical Abstract