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<p>Obesity is a global health challenge linked with NAFLD (nonalcoholic fatty liver disease). Bariatric surgery can induce NAFLD remission by altering gut microbiota. This study evaluates bariatric surgery’s effects on anthropometric indices, gut microbiota, and microbial metabolites in NAFLD patients. Data from major databases up to October 2023 were analyzed. Studies were assessed for quality using the Newcastle–Ottawa scale (NOS). Eleven studies were reviewed. Bariatric surgery increased <i>Bacteroides</i>, <i>Akkermansia</i>, and “Proteobacteria” and decreased “Actinomycetota.” It also altered bile acid profiles, reducing primary conjugated bile acids and increasing secondary conjugated bile acids, particularly glycoursodeoxycholic acid (GUDCA). Improvements in body mass index were observed in NAFLD patient’s post-surgery. Bariatric surgery impacts gut microbiota and bile acid profiles, playing a potential role in NAFLD remission. Further extensive studies are required due to study inconsistencies.</p>

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The effect of bariatric surgery on anthropometric indices, gut microbiome, and microbial metabolites in patients with NAFLD: a systematic review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月7日

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  • Aylin Hajizadeh,
  • Hanieh-Sadat Ejtahed,
  • Mohammad Reza Fadaeifard,
  • Fateme Ziamanesh,
  • Shirin Hasani-Ranjbar,
  • Mahboobeh Hemmatabadi,
  • Nooshin Shirzad

摘要

Obesity is a global health challenge linked with NAFLD (nonalcoholic fatty liver disease). Bariatric surgery can induce NAFLD remission by altering gut microbiota. This study evaluates bariatric surgery’s effects on anthropometric indices, gut microbiota, and microbial metabolites in NAFLD patients. Data from major databases up to October 2023 were analyzed. Studies were assessed for quality using the Newcastle–Ottawa scale (NOS). Eleven studies were reviewed. Bariatric surgery increased Bacteroides, Akkermansia, and “Proteobacteria” and decreased “Actinomycetota.” It also altered bile acid profiles, reducing primary conjugated bile acids and increasing secondary conjugated bile acids, particularly glycoursodeoxycholic acid (GUDCA). Improvements in body mass index were observed in NAFLD patient’s post-surgery. Bariatric surgery impacts gut microbiota and bile acid profiles, playing a potential role in NAFLD remission. Further extensive studies are required due to study inconsistencies.