Scholarlink

Background <p>Diabetic Peripheral Neuropathy (DPN) is a common and debilitating complication of diabetes, leading to significant morbidity. Conventional diagnostic methods such as nerve conduction studies (NCS) and clinical scores are often limited by invasiveness and inability to detect early neuropathic changes. Shear Wave Elastography (SWE), a novel ultrasonographic technique that quantifies tissue stiffness, offers potential for earlier and more accurate diagnosis.</p> Aim <p>To evaluate the role of Shear Wave Elastography in diagnosing Diabetic Peripheral Neuropathy and compare its diagnostic efficacy with conventional methods including NCS and ultrasonographic cross-sectional area (CSA) and echogenicity measurements.</p> Materials and methods <p>This prospective case–control study was conducted at Indira Gandhi Medical College, Shimla (January 2024–May 2025) and included 69 participants divided equally into three groups: (I) diabetics with DPN, (II) diabetics without DPN, and (III) healthy controls. All participants underwent Modified Toronto Clinical Neuropathy Scoring (mTCNS), laboratory evaluation, NCS, ultrasonography, and SWE of the tibial nerve 5&#xa0;cm above the medial malleolus. Statistical analysis was performed using SPSS v28.0, with <i>p</i> &lt; 0.05 considered significant.</p> Results <p>SWE values were significantly higher in patients with DPN (Right = 84.04 ± 37.37&#xa0;kPa; Left = 93.17 ± 41.46&#xa0;kPa) compared to diabetics without DPN and controls (<i>p</i> &lt; 0.001). Echogenicity was markedly reduced in DPN (Right = 28.7 pixels) versus controls (66.5 pixels). ROC analysis yielded SWE cutoff values of 53.5&#xa0;kPa (right) and 54&#xa0;kPa (left), with sensitivity = 82.6% and specificity = 86.9% (AUC = 0.918 and 0.833 respectively). CSA differences were not statistically significant.</p> Conclusion <p>Shear Wave Elastography demonstrates high sensitivity and specificity in detecting DPN, offering a non-invasive, rapid, and reliable alternative to conventional methods. Incorporating SWE into clinical practice may facilitate earlier diagnosis and better management of diabetic neuropathy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Role of shear wave elastography in evaluation of diabetic peripheral neuropathy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月28日

查看全文
  • Anupam Jhobta,
  • Mukesh Surya,
  • Rahul Kumar,
  • Anita Padam,
  • Satish Kumar

摘要

Background

Diabetic Peripheral Neuropathy (DPN) is a common and debilitating complication of diabetes, leading to significant morbidity. Conventional diagnostic methods such as nerve conduction studies (NCS) and clinical scores are often limited by invasiveness and inability to detect early neuropathic changes. Shear Wave Elastography (SWE), a novel ultrasonographic technique that quantifies tissue stiffness, offers potential for earlier and more accurate diagnosis.

Aim

To evaluate the role of Shear Wave Elastography in diagnosing Diabetic Peripheral Neuropathy and compare its diagnostic efficacy with conventional methods including NCS and ultrasonographic cross-sectional area (CSA) and echogenicity measurements.

Materials and methods

This prospective case–control study was conducted at Indira Gandhi Medical College, Shimla (January 2024–May 2025) and included 69 participants divided equally into three groups: (I) diabetics with DPN, (II) diabetics without DPN, and (III) healthy controls. All participants underwent Modified Toronto Clinical Neuropathy Scoring (mTCNS), laboratory evaluation, NCS, ultrasonography, and SWE of the tibial nerve 5 cm above the medial malleolus. Statistical analysis was performed using SPSS v28.0, with p < 0.05 considered significant.

Results

SWE values were significantly higher in patients with DPN (Right = 84.04 ± 37.37 kPa; Left = 93.17 ± 41.46 kPa) compared to diabetics without DPN and controls (p < 0.001). Echogenicity was markedly reduced in DPN (Right = 28.7 pixels) versus controls (66.5 pixels). ROC analysis yielded SWE cutoff values of 53.5 kPa (right) and 54 kPa (left), with sensitivity = 82.6% and specificity = 86.9% (AUC = 0.918 and 0.833 respectively). CSA differences were not statistically significant.

Conclusion

Shear Wave Elastography demonstrates high sensitivity and specificity in detecting DPN, offering a non-invasive, rapid, and reliable alternative to conventional methods. Incorporating SWE into clinical practice may facilitate earlier diagnosis and better management of diabetic neuropathy.