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<p>Ganglioneuromas are rare, benign neural crest-derived tumors capable of secreting catecholamines and clinically mimicking more aggressive neoplasms such as paragangliomas. We present the case of a 35-year-old woman with paroxysmal hypertension, palpitations, and exertional dyspnea, found to have catecholamine-induced dilated cardiomyopathy and a posterior mediastinal mass. Imaging suggested a paraganglioma, but histopathological and immunohistochemical evaluation confirmed a functional ganglioneuroma. CT demonstrated a soft‑tissue attenuation mass with progressive enhancement, and MRI revealed a distinctive whorled internal architecture, imaging features that closely mimicked a paraganglioma. Following preoperative alpha‑adrenergic blockade, complete surgical excision of the tumor led to resolution of symptoms, normalization of blood pressure, and significant improvement in cardiac function. This case emphasizes the importance of early recognition and multidisciplinary management of functional ganglioneuromas to prevent serious cardiovascular complications and ensure favorable outcomes.</p>

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Imaging in functional posterior mediastinal ganglioneuroma presenting with catecholamine-induced dilated cardiomyopathy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月18日

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  • Imran Salam Teeli,
  • Irfan Robbani

摘要

Ganglioneuromas are rare, benign neural crest-derived tumors capable of secreting catecholamines and clinically mimicking more aggressive neoplasms such as paragangliomas. We present the case of a 35-year-old woman with paroxysmal hypertension, palpitations, and exertional dyspnea, found to have catecholamine-induced dilated cardiomyopathy and a posterior mediastinal mass. Imaging suggested a paraganglioma, but histopathological and immunohistochemical evaluation confirmed a functional ganglioneuroma. CT demonstrated a soft‑tissue attenuation mass with progressive enhancement, and MRI revealed a distinctive whorled internal architecture, imaging features that closely mimicked a paraganglioma. Following preoperative alpha‑adrenergic blockade, complete surgical excision of the tumor led to resolution of symptoms, normalization of blood pressure, and significant improvement in cardiac function. This case emphasizes the importance of early recognition and multidisciplinary management of functional ganglioneuromas to prevent serious cardiovascular complications and ensure favorable outcomes.