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Background <p>Normative values of optic nerve sheath diameter (ONSD) are essential for establishing baseline measurements to differentiate normal from pathological states. This underscores the importance of generating population-specific normative values. Thus, this study aimed to determine the normative values of ONSD using magnetic resonance imaging (MRI) in normal adults from Southwestern Nigeria.</p> Methods <p>This retrospective study assessed brain MRI images reported to be normal from a Multisystem Hospital in Southwestern Nigeria, acquired between October 2024 and January 2025. A total of 163 patients, aged 15–90 years, were included. ONSDs were measured at 3&#xa0;mm and 8&#xa0;mm posterior to the globe for both eyes using electronic calipers on the picture archiving and communication system (PACS) workstation of the hospital. Measurements were taken by a single investigator. Statistical analysis was performed using SPSS version 23.</p> Results <p>The study included 90 females (55.2%) and 73 males (44.8%) with an average age of 45.63 ± 19.38 years. The mean ONSDs for the right eye at 3&#xa0;mm and 8&#xa0;mm from the globe were 5.05 ± 0.63&#xa0;mm and 4.37 ± 0.51&#xa0;mm, respectively. For the left eye, mean ONSDs were 5.06 ± 0.63&#xa0;mm and 4.37 ± 0.50&#xa0;mm. A very weak and statistically insignificant correlation was noted between ONSD measured at 3&#xa0;mm and 8&#xa0;mm and both gender and different age groups (<i>p</i> &gt; 0.05). No significant differences were observed between the right and left eyes’ ONSDs. However, a significant difference was observed in the ONSD measurements at 3&#xa0;mm and 8&#xa0;mm from the posterior globe margin for both eyes. The intra-class correlation coefficients (ICCs) for all measurements indicated excellent reliability, with values greater than 0.9.</p> Conclusion <p>This study established normative ONSD values for the Southwestern Nigerian population using MRI. These normative values are crucial for clinical practice and can aid in the early detection and monitoring of conditions related to elevated intracranial pressure.</p>

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Normative values of optic nerve sheath diameter in Southwestern Nigeria using magnetic resonance imaging

  • 期刊论文

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  • 发表日期：

    2025年7月21日

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  • Ikechukwu Emmanuel Onwunta,
  • Aminu Muzammil,
  • Ikenna Caleb Onyemauwa,
  • Stephen Chukwuebuka Ugwuobu,
  • Abdullahi Alfa,
  • Benjamin Ikemefuna Ude,
  • Ignatius Ajogu Nwigboji,
  • Ifeanyi Daniel Obatu,
  • Ebube Lilian Agbo

摘要

Background

Normative values of optic nerve sheath diameter (ONSD) are essential for establishing baseline measurements to differentiate normal from pathological states. This underscores the importance of generating population-specific normative values. Thus, this study aimed to determine the normative values of ONSD using magnetic resonance imaging (MRI) in normal adults from Southwestern Nigeria.

Methods

This retrospective study assessed brain MRI images reported to be normal from a Multisystem Hospital in Southwestern Nigeria, acquired between October 2024 and January 2025. A total of 163 patients, aged 15–90 years, were included. ONSDs were measured at 3 mm and 8 mm posterior to the globe for both eyes using electronic calipers on the picture archiving and communication system (PACS) workstation of the hospital. Measurements were taken by a single investigator. Statistical analysis was performed using SPSS version 23.

Results

The study included 90 females (55.2%) and 73 males (44.8%) with an average age of 45.63 ± 19.38 years. The mean ONSDs for the right eye at 3 mm and 8 mm from the globe were 5.05 ± 0.63 mm and 4.37 ± 0.51 mm, respectively. For the left eye, mean ONSDs were 5.06 ± 0.63 mm and 4.37 ± 0.50 mm. A very weak and statistically insignificant correlation was noted between ONSD measured at 3 mm and 8 mm and both gender and different age groups (p > 0.05). No significant differences were observed between the right and left eyes’ ONSDs. However, a significant difference was observed in the ONSD measurements at 3 mm and 8 mm from the posterior globe margin for both eyes. The intra-class correlation coefficients (ICCs) for all measurements indicated excellent reliability, with values greater than 0.9.

Conclusion

This study established normative ONSD values for the Southwestern Nigerian population using MRI. These normative values are crucial for clinical practice and can aid in the early detection and monitoring of conditions related to elevated intracranial pressure.