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Background <p>Our aim to assess the significance of new multi-parametric MRI techniques as intra-voxel incoherent motion (IVIM), T2* perfusion, T1 permeability and susceptibility-weighted images (SWI) in differentiating from recurrent tumor from post treatment changes.</p> Results <p>Forty-five patients were enrolled in the current study, 25 patients with recurrence and 20 with radiation necrosis. As regard the IVIM parameters, the perfusion fraction (f) and the pseudodiffusion (D*) component shows significant difference between radiation changes and recurrent tumor (<i>P</i> value = 0.01). The Ktrans showed significant difference between radiation changes and recurrent tumor (<i>P</i> value = 0.001). The proportion of dark signal intensity on susceptibility-weighted imaging (proSWI) showed significant difference between radiation changes and recurrent tumor (<i>P</i> value = 0.0001), while the diffusion component (D) showed no significant difference between radiation changes and recurrent tumor (<i>P</i> value = 0.282).</p> Conclusions <p>Multi-parametric new techniques as intra-voxel incoherent motion, susceptibility weighted images and post-contrast perfusion studies allow early and accurate differentiation of recurrent tumor from post radiation changes and thus improving the patients overall clinical outcome.</p>

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The value of intra-voxel incoherent motion, susceptibility-weighted images and post-contrast magnetic resonance perfusion studies in assessment of treatment response to brain tumor

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月2日

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  • Mena Elerian Youssef Ekladious,
  • Mina M. Gerges,
  • Samar Ramzy Ragheb

摘要

Background

Our aim to assess the significance of new multi-parametric MRI techniques as intra-voxel incoherent motion (IVIM), T2* perfusion, T1 permeability and susceptibility-weighted images (SWI) in differentiating from recurrent tumor from post treatment changes.

Results

Forty-five patients were enrolled in the current study, 25 patients with recurrence and 20 with radiation necrosis. As regard the IVIM parameters, the perfusion fraction (f) and the pseudodiffusion (D*) component shows significant difference between radiation changes and recurrent tumor (P value = 0.01). The Ktrans showed significant difference between radiation changes and recurrent tumor (P value = 0.001). The proportion of dark signal intensity on susceptibility-weighted imaging (proSWI) showed significant difference between radiation changes and recurrent tumor (P value = 0.0001), while the diffusion component (D) showed no significant difference between radiation changes and recurrent tumor (P value = 0.282).

Conclusions

Multi-parametric new techniques as intra-voxel incoherent motion, susceptibility weighted images and post-contrast perfusion studies allow early and accurate differentiation of recurrent tumor from post radiation changes and thus improving the patients overall clinical outcome.