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Background <p>Sickle cell disease is an inherited hemoglobinopathy resulting in chronic hemolysis and painful vaso-occlusive crises. Sickle vasculopathy caused by impaired nitric oxide bioavailability and arterial stiffness and associated with multiple complications.</p> Results <p>Mean age of patients was 13.85 ± 2.53 SD, 50% were males, 77.5% were homozygous sickle cell disease (SS). Brachial artery parameters showed that baseline diameter was significantly higher (<i>p</i> &lt; 0.001) and flow mediated dilatation (FMD) was significantly lower in patients than control (<i>p</i> &lt; 0.001). Carotid artery parameters showed that carotid intima-media thickness (CIMT) and cross-sectional distensability were significantly higher in sickle group than control (<i>p</i> 0.001, <i>p</i> 0.007). Diastolic shear stress and elastic modulus showed no significant difference between sickle and control group (<i>p</i> 0.071, <i>p</i> 0.083). Regarding sickle subgroups, carotid intima-media thickness was higher and cross-sectional compliance and distensability were lower in subgroup II than subgroup I (<i>p</i> &lt; 0.001, <i>p</i> &lt; 0.018, <i>p</i> &lt; 0.035), respectively.</p> Conclusion <p>Doppler assessment of brachial and carotid elastic properties may be helpful for early detection of sickle cell vasculopathy and sickle-related complications.</p>

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The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月21日

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  • Marwa Mohammed Mohammed Onsy,
  • Sonia Ali El-Saiedi,
  • Douaa Mohammed Mohammed Elsheshtawy,
  • Marwa Abd-Elhady Abd-Elsamad

摘要

Background

Sickle cell disease is an inherited hemoglobinopathy resulting in chronic hemolysis and painful vaso-occlusive crises. Sickle vasculopathy caused by impaired nitric oxide bioavailability and arterial stiffness and associated with multiple complications.

Results

Mean age of patients was 13.85 ± 2.53 SD, 50% were males, 77.5% were homozygous sickle cell disease (SS). Brachial artery parameters showed that baseline diameter was significantly higher (p < 0.001) and flow mediated dilatation (FMD) was significantly lower in patients than control (p < 0.001). Carotid artery parameters showed that carotid intima-media thickness (CIMT) and cross-sectional distensability were significantly higher in sickle group than control (p 0.001, p 0.007). Diastolic shear stress and elastic modulus showed no significant difference between sickle and control group (p 0.071, p 0.083). Regarding sickle subgroups, carotid intima-media thickness was higher and cross-sectional compliance and distensability were lower in subgroup II than subgroup I (p < 0.001, p < 0.018, p < 0.035), respectively.

Conclusion

Doppler assessment of brachial and carotid elastic properties may be helpful for early detection of sickle cell vasculopathy and sickle-related complications.