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Background <p>Sepsis is a dysregulated host response to infection, which is considered a critical health problem with significant morbidity and mortality in pediatric age group. It continues to pose a significant burden in low- and middle-income countries. This study aimed to investigate the prevalence, characteristics, and outcome of severe sepsis in pediatric patients admitted to pediatric intensive care units (PICUs) at three of the largest tertiary care hospitals, Cairo, Egypt, to identify the predictors associated with morbidity and mortality in severe sepsis in a limited-resource setting.</p> Methods <p>This prospective cohort study included critically ill infants and children aged 29&#xa0;days to 18&#xa0;years admitted to the 3 PICUs with a confirmed diagnosis of sepsis during a 6-month period from April to October 2021. Detailed history, comprehensive clinical examination, laboratory and radiological investigations as well as management and outcome were recorded.</p> Results <p>A total of 432 patients were prospectively enrolled. The most common presentations were disturbed consciousness, respiratory distress, shock, and status epilepticus (61.6%, 56.5%, 38%, and 25% respectively). Community-acquired infections predominated (62%) over hospital-acquired infections (38%). Over half of the patients (56%) recovered without sequelae, while overall mortality was 17.6%. A pSOFA score &gt; 10 was associated with the highest mortality. Impaired kidney function, elevated bilirubin, and high CRP levels were strongly correlated with sepsis related mortality.</p> Conclusions <p>Pediatric sepsis remains a major health problem with high mortality rate in limited-resource countries as Egypt. The current study aimed to set an epidemiological profile of severe sepsis in a big cohort Egyptian infants and children admitted to 3 PICUs. The resulting data can offer foundation for crafting predictive models targeting sepsis in pediatric age group, as well as for designing interventions to enhance outcome in limited resource countries.</p>

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The prevalence, characteristics, and outcome of severe sepsis at three pediatric intensive care units in a limited-resource setting: a prospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月6日

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  • Enas Abdallah Ali Abdallah,
  • Hala H. Mansour,
  • Mortada El-Shabrawi,
  • Sally Kamal Ibrahim Ishak,
  • Mo’men Mohammed Abd-Elmawgood Kebesy,
  • Eman Mohamed Ibraheim Moawad

摘要

Background

Sepsis is a dysregulated host response to infection, which is considered a critical health problem with significant morbidity and mortality in pediatric age group. It continues to pose a significant burden in low- and middle-income countries. This study aimed to investigate the prevalence, characteristics, and outcome of severe sepsis in pediatric patients admitted to pediatric intensive care units (PICUs) at three of the largest tertiary care hospitals, Cairo, Egypt, to identify the predictors associated with morbidity and mortality in severe sepsis in a limited-resource setting.

Methods

This prospective cohort study included critically ill infants and children aged 29 days to 18 years admitted to the 3 PICUs with a confirmed diagnosis of sepsis during a 6-month period from April to October 2021. Detailed history, comprehensive clinical examination, laboratory and radiological investigations as well as management and outcome were recorded.

Results

A total of 432 patients were prospectively enrolled. The most common presentations were disturbed consciousness, respiratory distress, shock, and status epilepticus (61.6%, 56.5%, 38%, and 25% respectively). Community-acquired infections predominated (62%) over hospital-acquired infections (38%). Over half of the patients (56%) recovered without sequelae, while overall mortality was 17.6%. A pSOFA score > 10 was associated with the highest mortality. Impaired kidney function, elevated bilirubin, and high CRP levels were strongly correlated with sepsis related mortality.

Conclusions

Pediatric sepsis remains a major health problem with high mortality rate in limited-resource countries as Egypt. The current study aimed to set an epidemiological profile of severe sepsis in a big cohort Egyptian infants and children admitted to 3 PICUs. The resulting data can offer foundation for crafting predictive models targeting sepsis in pediatric age group, as well as for designing interventions to enhance outcome in limited resource countries.