Scholarlink

Background <p>Idiopathic nephrotic syndrome (INS) is a common childhood kidney disorder that increases the risk of cardiovascular disorders (CVD) due to hyperlipidemia and hypertension. Elevated carotid intima-media thickness (CIMT) indicates early vascular changes. This study aimed to evaluate the CIMT in children with INS and correlate it with some CVD risk factors.</p> Methods <p>This cross-sectional study enrolled 35 children diagnosed with INS who had been observed for a minimum of one year at the nephrology clinic, along with 35 matched healthy individuals. All participants underwent physical examinations and tests, including a lipid profile, renal function, serum albumin, hemoglobin levels, and an ultrasound to measure CIMT.</p> Results <p>The study included patients with a mean age of 7.9 ± 4.3 years, primarily males, with an average INS duration of 4.21 ± 2.25 years. The study didn’t find a significant difference in BMI between the two groups (<i>p</i> = 0.06). However, the patients had a significantly higher mean diastolic blood pressure (BP) than the controls (<i>p</i> = 0.001), while no notable difference was observed in mean systolic BP between both groups. The study found that patients with INS had a mean CIMT of 0.42 ± 0.08 mm (95% CI 0.39–0.45), significantly higher than the control group's 0.35 mm ± 0.023 (95% CI 0.34–0.36) (<i>p</i> &lt; 0.001). There was a positive correlation between CIMT and the patient's age (<i>r</i> = 0.52, <i>p</i> &lt; 0.001), disease duration (<i>r</i> = 0.457, <i>p</i> = 0.006), and low-density lipoprotein (<i>r</i> = 0.67, <i>p</i> &lt; 0.001), while CIMT negatively correlated with high-density lipoprotein (r = -0.58, <i>p</i> &lt; 0.001), urinary albumin-creatinine ratio (<i>r</i> = -0.49, <i>p</i> = 0.002), and serum hemoglobin levels (<i>r</i> = -0.553, <i>p</i> = 0.001).</p> Conclusions <p>Children with INS are not exactly at higher risk for dyslipidemia, but this can be part of the syndrome. CIMT measurement enables early detection of cardiovascular complications in children with INS.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Carotid intima-media thickness in children with nephrotic syndrome: a cross-sectional study compared with healthy children

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月16日

查看全文
  • Rasha Helmy,
  • Sara Mahmoud Kamel,
  • ِAhmed Badr,
  • Ahmed Mohamed Zaki,
  • Yasmin Ramadan

摘要

Background

Idiopathic nephrotic syndrome (INS) is a common childhood kidney disorder that increases the risk of cardiovascular disorders (CVD) due to hyperlipidemia and hypertension. Elevated carotid intima-media thickness (CIMT) indicates early vascular changes. This study aimed to evaluate the CIMT in children with INS and correlate it with some CVD risk factors.

Methods

This cross-sectional study enrolled 35 children diagnosed with INS who had been observed for a minimum of one year at the nephrology clinic, along with 35 matched healthy individuals. All participants underwent physical examinations and tests, including a lipid profile, renal function, serum albumin, hemoglobin levels, and an ultrasound to measure CIMT.

Results

The study included patients with a mean age of 7.9 ± 4.3 years, primarily males, with an average INS duration of 4.21 ± 2.25 years. The study didn’t find a significant difference in BMI between the two groups (p = 0.06). However, the patients had a significantly higher mean diastolic blood pressure (BP) than the controls (p = 0.001), while no notable difference was observed in mean systolic BP between both groups. The study found that patients with INS had a mean CIMT of 0.42 ± 0.08 mm (95% CI 0.39–0.45), significantly higher than the control group's 0.35 mm ± 0.023 (95% CI 0.34–0.36) (p < 0.001). There was a positive correlation between CIMT and the patient's age (r = 0.52, p < 0.001), disease duration (r = 0.457, p = 0.006), and low-density lipoprotein (r = 0.67, p < 0.001), while CIMT negatively correlated with high-density lipoprotein (r = -0.58, p < 0.001), urinary albumin-creatinine ratio (r = -0.49, p = 0.002), and serum hemoglobin levels (r = -0.553, p = 0.001).

Conclusions

Children with INS are not exactly at higher risk for dyslipidemia, but this can be part of the syndrome. CIMT measurement enables early detection of cardiovascular complications in children with INS.