Scholarlink

Purpose <p>Cerebral palsy (CP) frequently results in developmental delays and long-term physical impairment. This study aims to evaluate serum biochemical and extracellular biomarkers, specifically matrix metalloproteinases (MMP-2 and MMP-9), in children with CP as an initial step to investigate their potential involvement in the condition’s etiopathogenesis.</p> Methods <p>Forty children diagnosed with CP and 20 healthy age-matched study participants were included. Demographic and clinical data were collected using a structured proforma. Serum samples were analyzed for biochemical parameters (ALT, AST, ALP, total protein, albumin, creatinine, uric acid, bilirubin, and electrolytes) and MMP levels.</p> Results <p>Study revealed significant differences between CP patients and the healthy group. CP patients exhibited lower levels of total protein, albumin, magnesium, and phosphorus but higher levels of creatinine, uric acid, chloride, and total bilirubin. Elevated liver enzyme levels, although observed, showed variable statistical significance. However, the serum level of MMP-9 was markedly elevated in CP patients, highlighting its potential role in blood-brain barrier disruption and tissue damage. The MMP-2 level in CP patients was mildly high, which was statistically non-significant. The demographic analysis indicated higher CP prevalence in rural areas, with parental consanguinity being a notable factor. Mixed CP was the most common subtype observed (57%).</p> Conclusion <p>This study highlights the systemic impact of CP on biochemical and extracellular markers, particularly the role of MMP-9 in disease pathology. These findings provide valuable insights into CP’s etiopathogenesis, paving the way for further research and potential therapeutic interventions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Matrix metalloproteinases and biochemical dysregulation in pediatric cerebral palsy: a clinical perspective

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月7日

查看全文
  • Kaleem Maqsood,
  • Wizdah Chuhdary,
  • Humera Naveed,
  • Nabila Roohi

摘要

Purpose

Cerebral palsy (CP) frequently results in developmental delays and long-term physical impairment. This study aims to evaluate serum biochemical and extracellular biomarkers, specifically matrix metalloproteinases (MMP-2 and MMP-9), in children with CP as an initial step to investigate their potential involvement in the condition’s etiopathogenesis.

Methods

Forty children diagnosed with CP and 20 healthy age-matched study participants were included. Demographic and clinical data were collected using a structured proforma. Serum samples were analyzed for biochemical parameters (ALT, AST, ALP, total protein, albumin, creatinine, uric acid, bilirubin, and electrolytes) and MMP levels.

Results

Study revealed significant differences between CP patients and the healthy group. CP patients exhibited lower levels of total protein, albumin, magnesium, and phosphorus but higher levels of creatinine, uric acid, chloride, and total bilirubin. Elevated liver enzyme levels, although observed, showed variable statistical significance. However, the serum level of MMP-9 was markedly elevated in CP patients, highlighting its potential role in blood-brain barrier disruption and tissue damage. The MMP-2 level in CP patients was mildly high, which was statistically non-significant. The demographic analysis indicated higher CP prevalence in rural areas, with parental consanguinity being a notable factor. Mixed CP was the most common subtype observed (57%).

Conclusion

This study highlights the systemic impact of CP on biochemical and extracellular markers, particularly the role of MMP-9 in disease pathology. These findings provide valuable insights into CP’s etiopathogenesis, paving the way for further research and potential therapeutic interventions.