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Introduction <p>Despite its clinical significance, the precise pathogenesis of nephrotic syndrome (NS) remains elusive, with genetic factors and immune dysregulation implicated in disrupting glomerular filtration. Among these factors, TNF-α gene polymorphisms, such as the -<i>308 G/A</i> (<i>rs1800629</i>) polymorphism, have garnered attention in association studies with childhood NS. However, conflicting findings necessitate a comprehensive meta-analysis to delineate more precise estimates.</p> Methods <p>Relevant literature was searched in PubMed, Web of Science, and Google Scholar (title search only) until September 15, 2024. Studies that determine the association of the <i>rs1800629</i> among NS vs. controls were retrieved and synthesized to compute for the odds ratios and 95% confidence interval using Review Manager 5.4.</p> Results <p>Utilizing various genetic models, including allelic, co-dominant, dominant, and recessive models, significant associations were found between the <i>rs1800629</i> polymorphism and NS susceptibility, favoring disease development in the presence of the variant allele. Based on geographic location and adjustment for factors like Hardy–Weinberg equilibrium and age groups, subgroup analyses reinforced these findings. Notably, the Asian subgroup exhibited stronger associations compared to non-Asians.</p> Conclusion <p>The present meta-analysis showed that the <i>rs1800629</i> polymorphism is associated with NS susceptibility. However, despite the robustness of these results, further large-scale and prospective studies are warranted to validate these conclusions comprehensively.</p>

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Association of the rs1800629 polymorphism in the TNF-α gene with nephrotic syndrome development: evidence from an updated meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月28日

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  • Raphael Enrique Tiongco,
  • Neil David Cayanan,
  • Michael John Dominguez,
  • Ma. Theresa Mae Doctora,
  • Julie Ann Mercado

摘要

Introduction

Despite its clinical significance, the precise pathogenesis of nephrotic syndrome (NS) remains elusive, with genetic factors and immune dysregulation implicated in disrupting glomerular filtration. Among these factors, TNF-α gene polymorphisms, such as the -308 G/A (rs1800629) polymorphism, have garnered attention in association studies with childhood NS. However, conflicting findings necessitate a comprehensive meta-analysis to delineate more precise estimates.

Methods

Relevant literature was searched in PubMed, Web of Science, and Google Scholar (title search only) until September 15, 2024. Studies that determine the association of the rs1800629 among NS vs. controls were retrieved and synthesized to compute for the odds ratios and 95% confidence interval using Review Manager 5.4.

Results

Utilizing various genetic models, including allelic, co-dominant, dominant, and recessive models, significant associations were found between the rs1800629 polymorphism and NS susceptibility, favoring disease development in the presence of the variant allele. Based on geographic location and adjustment for factors like Hardy–Weinberg equilibrium and age groups, subgroup analyses reinforced these findings. Notably, the Asian subgroup exhibited stronger associations compared to non-Asians.

Conclusion

The present meta-analysis showed that the rs1800629 polymorphism is associated with NS susceptibility. However, despite the robustness of these results, further large-scale and prospective studies are warranted to validate these conclusions comprehensively.