Scholarlink

Background <p>Sepsis is a significant contributor to pediatric mortality, particularly in low- and middle-income countries. Cytokines regulate the immune response to infection and, also, play a key role in regulating inflammation. Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) have been proposed a potential biomarkers for predicting severity of illness and mortality in children with sepsis.</p> Aim <p>This study evaluates the prognostic value of TGF-β and IL-6 as biomarkers for predicting mortality among children with sepsis.</p> Methods <p>A prospective cohort study was conducted involving 40 pediatric patients diagnosed with sepsis, enrolled from the placebo group of a randomized controlled trial. We assessed clinical parameters, including Pediatric SOFA and PRISM III scores, alongside serum levels of IL-6 and TGF-β on admission and day seven. Mortality rates, length of PICU stay, and comparisons of cytokine levels between sepsis survivors and non-survivors were assessed.</p> Results <p>Higher median IL-6 levels were significantly associated with non-survivors (22&#xa0;pg/mL vs. 15&#xa0;pg/mL, <i>p</i> = 0.032). The Pediatric SOFA and PRISM III scores were also significantly elevated in non-survivors (pediatric SOFA median, 9 vs. 6, <i>p</i> = 0.007; PRISM III score median, 12 vs. 9, <i>p</i> = 0.028). TGF-β levels had no significant difference between survivors and non-survivors (<i>p</i> = 0.250). IL-6 demonstrated an AUC of 0.721 (<i>p</i> = 0.033) for predicting mortality, while TGF-β had a low AUC of 0.381 (<i>p</i> = 0.250), indicating poor prognostic value.</p> Conclusions <p>IL-6 is a valuable prognostic mortality marker in pediatric sepsis patients, whereas TGF-β does not demonstrate similar predictive utility. These findings highlight the importance of incorporating IL-6 in the clinical assessment of pediatric sepsis in resource-limited settings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluating transforming growth factor-B and interleukin-6 as a prognostic markers in pediatric critically ill septic patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月2日

查看全文
  • Ayman Emil Eskander,
  • Hanaa Ibrahim Rady,
  • Mariam Mahmoud Balah,
  • Heba Ibrahim Abdallah,
  • Noha Hassan El-Anwar

摘要

Background

Sepsis is a significant contributor to pediatric mortality, particularly in low- and middle-income countries. Cytokines regulate the immune response to infection and, also, play a key role in regulating inflammation. Transforming growth factor-β (TGF-β) and interleukin-6 (IL-6) have been proposed a potential biomarkers for predicting severity of illness and mortality in children with sepsis.

Aim

This study evaluates the prognostic value of TGF-β and IL-6 as biomarkers for predicting mortality among children with sepsis.

Methods

A prospective cohort study was conducted involving 40 pediatric patients diagnosed with sepsis, enrolled from the placebo group of a randomized controlled trial. We assessed clinical parameters, including Pediatric SOFA and PRISM III scores, alongside serum levels of IL-6 and TGF-β on admission and day seven. Mortality rates, length of PICU stay, and comparisons of cytokine levels between sepsis survivors and non-survivors were assessed.

Results

Higher median IL-6 levels were significantly associated with non-survivors (22 pg/mL vs. 15 pg/mL, p = 0.032). The Pediatric SOFA and PRISM III scores were also significantly elevated in non-survivors (pediatric SOFA median, 9 vs. 6, p = 0.007; PRISM III score median, 12 vs. 9, p = 0.028). TGF-β levels had no significant difference between survivors and non-survivors (p = 0.250). IL-6 demonstrated an AUC of 0.721 (p = 0.033) for predicting mortality, while TGF-β had a low AUC of 0.381 (p = 0.250), indicating poor prognostic value.

Conclusions

IL-6 is a valuable prognostic mortality marker in pediatric sepsis patients, whereas TGF-β does not demonstrate similar predictive utility. These findings highlight the importance of incorporating IL-6 in the clinical assessment of pediatric sepsis in resource-limited settings.