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Background <p>Asthma and obesity prevalence has increased exponentially over the last few decades. Obesity is an inflammatory disease that exerts its negative effect on asthma through several mechanisms one of which is insulin resistance. Recently, it has been shown that IR can negatively affect pulmonary functions independently. So, this study aimed to evaluate the relationship and impact of IR (HOMA-IR) on pulmonary lung functions in the obese and asthmatic pediatric population.</p> Methods <p>The study included 80 children with an age range (5–12&#xa0;years) subdivided into 4 groups of twenty each; group I: normal-weight asthmatics; group II: obese non-asthmatics; group III: obese asthmatics; and group IV: normal-weight non-asthmatics (control group). Full clinical history was taken, waist circumference and pulmonary functions were done and HOMA-IR was calculated. Insulin resistance was considered in children with HOMA-IR values above 2.6.</p> Results <p>HOMA-IR correlated positively with BMI with <i>r</i> = 0.6374 <i>p</i>-value &lt; 0.001 and waist circumference with <i>r</i> = 0.6 <i>p</i>-value &lt; 0.001. Meanwhile, HOMA-IR negatively correlated in the whole cohort with FEV1/FVC and FEF 50% with <i>p</i> =  &lt; 0.001, <i>r</i> = –0.398; <i>p</i> = 0.004, <i>r</i> =  − 0.15, respectively. Asthmatic patients (groups I and III) with HOMA-IR &gt; 2.6 showed statistically significantly lower FEV1/FVC compared to patients with HOMA-IR &lt; 2.6 with a <i>p</i>-value of 0.040.</p> Conclusion <p>IR was shown to negatively impact pulmonary functions independent of obesity. Thus earlier detection of metabolic derangements is crucial to protect the lungs in the long term. A trial of therapies targeting IR may benefit asthma control in such patients.</p>

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Impact of insulin resistance and hyperinsulinemia on pulmonary functions in asthmatic children: a cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月6日

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  • Abla S. Mostafa,
  • Shaimaa Elbehairy,
  • Christine W.S. Basanti,
  • Aya Mohamed Taher,
  • Yomna Ahmed Hosni,
  • Yasmin Saied

摘要

Background

Asthma and obesity prevalence has increased exponentially over the last few decades. Obesity is an inflammatory disease that exerts its negative effect on asthma through several mechanisms one of which is insulin resistance. Recently, it has been shown that IR can negatively affect pulmonary functions independently. So, this study aimed to evaluate the relationship and impact of IR (HOMA-IR) on pulmonary lung functions in the obese and asthmatic pediatric population.

Methods

The study included 80 children with an age range (5–12 years) subdivided into 4 groups of twenty each; group I: normal-weight asthmatics; group II: obese non-asthmatics; group III: obese asthmatics; and group IV: normal-weight non-asthmatics (control group). Full clinical history was taken, waist circumference and pulmonary functions were done and HOMA-IR was calculated. Insulin resistance was considered in children with HOMA-IR values above 2.6.

Results

HOMA-IR correlated positively with BMI with r = 0.6374 p-value < 0.001 and waist circumference with r = 0.6 p-value < 0.001. Meanwhile, HOMA-IR negatively correlated in the whole cohort with FEV1/FVC and FEF 50% with p =  < 0.001, r = –0.398; p = 0.004, r =  − 0.15, respectively. Asthmatic patients (groups I and III) with HOMA-IR > 2.6 showed statistically significantly lower FEV1/FVC compared to patients with HOMA-IR < 2.6 with a p-value of 0.040.

Conclusion

IR was shown to negatively impact pulmonary functions independent of obesity. Thus earlier detection of metabolic derangements is crucial to protect the lungs in the long term. A trial of therapies targeting IR may benefit asthma control in such patients.