Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia

期刊论文
出版模式：

开放获取
发表日期：

2024年2月12日

查看全文

Salah Aref,
Omnyia Khaled,
Nadia El Menshawy,
Emad Azmy,
Mohamed Aref,
Osama Salama,
Nada Khaled

摘要

Objective

This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients’ outcomes.

Methods

SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls.

Results

Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0.001, P = 0.003 respectively) as compared to control, and decline at complete remission (CR) and elevated again at relapse. High SOX2 and OCT3/4 levels were significantly correlated with the presence of adverse risk stratification parameters.

Conclusion

Our findings indicated that both SOX2 and OCT3/4 could serve as biomarkers that could improve risk stratification of acute leukemia patients. Also, both SOX2 and OCT3/4 might be a therapeutic target, especially in resistant acute leukemia.