Background <p>Self-regulation is a core phenomenon in child psychology. The Dysregulation Profile (DP), a composite scale that results from adding up three scores of the Child Behavior Checklist (CBCL 6–18), has emerged during the last two decades as a transdiagnostic construct in child and adolescent psychiatry that reflects serious difficulties in self-regulation, including emotional and behavioral dysregulation. This work aimed to investigate the prevalence of DP in a clinical sample compared to a community sample of Egyptian youth and to explore the potential demographic and clinical correlates of this phenomenon.</p> Methods <p>The electronic scoring records of the previously validated Arabic version of the CBCL 6–18 were reviewed for a large clinical sample of convenience (<i>n</i> = 3642, age range 6–18) and another community sample (<i>n</i> = 595) previously recruited by our group with the same age range. The prevalence and the clinical correlates of the Dysregulation Profile (DP) of the CBCL were investigated.</p> Results <p>Almost one-third of the clinical sample (33.1%) had a positive DP (≥ 210) in comparison to 4.2% of the community sample. No statistically significant differences were noted in mean age, age category (children versus adolescents), or sex between DP + ve and DP − ve youth in any of the two samples. DP was most associated with affective disorders and negatively correlated with social competence in both clinical and community samples.</p> Conclusions <p>Dysregulation Profile (DP) commonly coexists with other psychiatric disorders, especially affective disorders, in Egyptian youth regardless of sex and age category.</p>