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<p>Women of reproductive age suffer from a complex, multifactorial neuroendocrine and metabolic and reproductive dysfunction called polycystic ovary syndrome (PCOS), which has symptoms such as hormonal imbalance, irregular menstruation, and impaired metabolism. PCOS is estimated to affect between 8 and 13 per cent of the female population worldwide but is widely underdiagnosed. Some of the negative effects of PCOS include infertility, obesity, insulin resistance, and chronic physical and mental health problems. Lifestyle choices, diet, genetics, and environmental stressors all contribute to the development of PCOS through changes in steroidogenesis and other physiological processes that occur in the ovaries and the metabolism of women. Recent findings indicate that probiotic and prebiotic treatments may restore gut microbiota balance and promote increased metabolism. This review describes how the gut microbiome and the excessive production of female hormones (hyperandrogenism) in women with PCOS may interact and outlines potential pathways through which gut dysbiosis can contribute to the development of PCOS. Finally, this review highlights the integration of personalised lifestyle modifications and microbiota-targeted interventions as a multifaceted strategy to mitigate gut dysbiosis and improve the metabolic and endocrine outcomes associated with PCOS.</p>

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The interaction between polycystic ovary syndrome (PCOS) and gut microbiota: pathophysiology, clinical manifestations, and therapeutic approaches

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月19日

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  • Srishti Santosh Mukadam,
  • Sury Pratap Singh,
  • Tiyasha Tiyasha,
  • Gaurang Jain,
  • Astha Jangid,
  • Rupesh Gupta,
  • Vinay Kumar

摘要

Women of reproductive age suffer from a complex, multifactorial neuroendocrine and metabolic and reproductive dysfunction called polycystic ovary syndrome (PCOS), which has symptoms such as hormonal imbalance, irregular menstruation, and impaired metabolism. PCOS is estimated to affect between 8 and 13 per cent of the female population worldwide but is widely underdiagnosed. Some of the negative effects of PCOS include infertility, obesity, insulin resistance, and chronic physical and mental health problems. Lifestyle choices, diet, genetics, and environmental stressors all contribute to the development of PCOS through changes in steroidogenesis and other physiological processes that occur in the ovaries and the metabolism of women. Recent findings indicate that probiotic and prebiotic treatments may restore gut microbiota balance and promote increased metabolism. This review describes how the gut microbiome and the excessive production of female hormones (hyperandrogenism) in women with PCOS may interact and outlines potential pathways through which gut dysbiosis can contribute to the development of PCOS. Finally, this review highlights the integration of personalised lifestyle modifications and microbiota-targeted interventions as a multifaceted strategy to mitigate gut dysbiosis and improve the metabolic and endocrine outcomes associated with PCOS.