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Objectives <p>To Exploring the factors influencing the endometrial implantation window in IVF/ICSI cycles.</p> Methods <p>This study included a total of 191 women who undergone IVF/ICSI for infertility at our hospital from 2021 to 2024 and had undergone endometrial receptivity array testing. Due to the small number of participants in the post-receptive phase group(1individuals), including this group would lead to significant statistical bias, therefore, this study did not include this experimental group. Consequently, the actual number of subjects included in this study was 190, and based on the window period, the subjects were divided into two groups: pre-receptive phase (58 individuals) and receptive phase (132 individuals). So in this article, changes in endometrial receptivity refered only to changes in the “pre-receptive”.</p> Main outcome measures <p>To examine whether age, AMH, BMI, total cholesterol, triglyceride, and fasting plasma glucose had an effect on the endometrial window or contributed to the advancement of the endometrial implantation window and whether they can predict the endometrial window.</p> Results <p>There was no relationgship between age, BMI, total cholesterol, triglyceride, and fasting plasma glucose and endometrial receptivity. AMH showed a monotonically decreasing relationship, and the results of the logistic regression indicated OR = 0.866 (95% CI: 0.767-0.978, P = 0.021), which had statistical significance (Table 2). Therefore, it could be generally concluded that AMH was negatively correlated with endometrial receptivity. Furthermore, a ROC curve was plotted, with an area under the curve of 0.586 (95% CI: 0.494-0.678), and the optimal cutoff point was 2.0.</p> Conclusions <p>Serum AMH is negatively correlated with the prediction of the endometrialimplantation window. When serum AMH is at 2.0 ng/ml, the accuracy and sensitivity of predicting the endometrial receptivity are both at their highest. The effect of AMH onendometrial receptivity may be mediated through the AMHR-II receptor. </p>

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Exploring the factors influencing the endometrial implantation window in IVF/ICSI cycles: serum AMH is correlated with endometrial receptivity

  • 期刊论文

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  • 发表日期：

    2025年11月19日

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  • Xusheng Zhao,
  • Chunyan Ji,
  • Lingling Liu,
  • Yue Zhao,
  • Wei Wang

摘要

Objectives

To Exploring the factors influencing the endometrial implantation window in IVF/ICSI cycles.

Methods

This study included a total of 191 women who undergone IVF/ICSI for infertility at our hospital from 2021 to 2024 and had undergone endometrial receptivity array testing. Due to the small number of participants in the post-receptive phase group(1individuals), including this group would lead to significant statistical bias, therefore, this study did not include this experimental group. Consequently, the actual number of subjects included in this study was 190, and based on the window period, the subjects were divided into two groups: pre-receptive phase (58 individuals) and receptive phase (132 individuals). So in this article, changes in endometrial receptivity refered only to changes in the “pre-receptive”.

Main outcome measures

To examine whether age, AMH, BMI, total cholesterol, triglyceride, and fasting plasma glucose had an effect on the endometrial window or contributed to the advancement of the endometrial implantation window and whether they can predict the endometrial window.

Results

There was no relationgship between age, BMI, total cholesterol, triglyceride, and fasting plasma glucose and endometrial receptivity. AMH showed a monotonically decreasing relationship, and the results of the logistic regression indicated OR = 0.866 (95% CI: 0.767-0.978, P = 0.021), which had statistical significance (Table 2). Therefore, it could be generally concluded that AMH was negatively correlated with endometrial receptivity. Furthermore, a ROC curve was plotted, with an area under the curve of 0.586 (95% CI: 0.494-0.678), and the optimal cutoff point was 2.0.

Conclusions

Serum AMH is negatively correlated with the prediction of the endometrialimplantation window. When serum AMH is at 2.0 ng/ml, the accuracy and sensitivity of predicting the endometrial receptivity are both at their highest. The effect of AMH onendometrial receptivity may be mediated through the AMHR-II receptor.