Scholarlink

Background <p>Hepatitis B virus (HBV) infection is a major global health issue, affecting millions of individuals worldwide. Chronic HBV infection is associated with various systemic health complications, including liver disease with its impact on reproductive health in male fertility.</p> Methods <p>This study investigated the impact of HBV on sperm quality in a cohort of 1566 male infertile patients undergoing assisted reproductive treatment from 2021 to 2024. Patients aged 23 to 40&#xa0;years (mean age 34.2 ± 3.62&#xa0;years) were categorized into HBV-positive (783 cases) and HBV-negative (783 cases) groups based on serological tests for hepatitis B surface antigen (Hbs Ag).</p> Results <p>HBV-positive and HBV-negative groups exhibited significantly lower progressive motility (41.3% vs. 43.0%; <i>P</i> = 0.006), sperm concentration (53.6 vs. 59.8 × 10<sup>6</sup>/mL; <i>P</i> = 0.009), and normal morphology (4.5% vs. 5.0%; <i>P</i> &lt; 0.001), with reduced viability (<i>P</i> = 0.027). No differences were observed in semen volume (<i>P</i> = 0.807) or DNA fragmentation index (<i>P</i> = 0.970).</p> Conclusion <p>HBV infection is associated with impaired sperm motility, concentration, and morphology in infertile men.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Hepatitis B virus infection is associated with impaired sperm quality: a retrospective cohort study of 1566 infertile men

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月8日

查看全文
  • Yi Mo,
  • Fangfang Liang,
  • Hui Wei,
  • Bowen Wei,
  • Arshad Mehmood,
  • Sien Mo,
  • Dinggan Mo,
  • Honghao Peng,
  • Zheng Li,
  • Gang Liu,
  • Zhong Lin

摘要

Background

Hepatitis B virus (HBV) infection is a major global health issue, affecting millions of individuals worldwide. Chronic HBV infection is associated with various systemic health complications, including liver disease with its impact on reproductive health in male fertility.

Methods

This study investigated the impact of HBV on sperm quality in a cohort of 1566 male infertile patients undergoing assisted reproductive treatment from 2021 to 2024. Patients aged 23 to 40 years (mean age 34.2 ± 3.62 years) were categorized into HBV-positive (783 cases) and HBV-negative (783 cases) groups based on serological tests for hepatitis B surface antigen (Hbs Ag).

Results

HBV-positive and HBV-negative groups exhibited significantly lower progressive motility (41.3% vs. 43.0%; P = 0.006), sperm concentration (53.6 vs. 59.8 × 106/mL; P = 0.009), and normal morphology (4.5% vs. 5.0%; P < 0.001), with reduced viability (P = 0.027). No differences were observed in semen volume (P = 0.807) or DNA fragmentation index (P = 0.970).

Conclusion

HBV infection is associated with impaired sperm motility, concentration, and morphology in infertile men.