Role of neuropeptides in patients with endometriosis: a literature review

This article provides an overview of the role of neuropeptides in endometriosis.

Main body.

While the pathogenesis of endometriosis is not discovered exactly yet, researchers have explored endocrine, paracrine, and immunological influences to better understand the disease. Neuropeptides, which play a significant role in regulating communication among endometrial cells, have been extensively studied and found to have effects on neurons and other somatic cells. The interplay between neuropeptides, pain, and the immune response suggests that neuropeptides may play a significant role in the development and progression of endometriosis.

We investigate the role of nerve fibers and neuropeptides, estrogen and estrogen receptors, and new biomarkers in promoting inflammation and pain in endometriosis. Further research should focus on the roles and therapeutic potential of neuropeptides in endometriosis.